HLA-DR expression on monocytes and systemic inflammation in patients with ruptured abdominal aortic aneurysms.
HLA-DR expression on monocytes and systemic inflammation in patients with ruptured abdominal aortic aneurysms.
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DOI：
10.1186/cc5017
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Zwaveling JH
中科院分区：
文献类型：
--
作者：
Haveman JW;van den Berg AP;Verhoeven EL;Nijsten MW;van den Dungen JJ;The HT;Zwaveling JH
腹主动脉瘤破裂（RAAA）的死亡率仍然很高。严重的全身炎症，导致多器官功能衰竭，往往发生在这些患者。在这项研究中，我们描述了HLA-DR的表达水平在一个连续组的患者手术后RAAA和比较结果之间的幸存者和非幸存者。对IL-6和IL-10水平和序贯器官衰竭评估（SOFA）评分进行类似的比较。这是一项前瞻性观察性研究。对RAAA患者进行了前瞻性分析。在第1、3、5、7、10和14天采集血样。通过流式细胞术测量表达HLA-DR的CD-14阳性单核细胞的分数。通过ELISA测量IL-6和IL-10水平。该研究纳入了30例中位年龄为70岁的患者，其中27例（90%）为男性。6例患者死于多器官功能衰竭，其余患者均存活。在第1天至第14天，非存活者的SOFA评分显著较高。在非存活者中，单核细胞上的HLA-DR表达在第3、5、7、10和14天显著降低。IL-6和IL-10水平分别在第1天和第1和3天在非幸存者中显著较高。单核细胞HLA-DR表达下降，尤其是在死亡者中。所有RAAA患者均表现出严重的炎症和抗炎反应，IL-6和IL-10的产生增加。术后3天内IL-6和IL-10水平升高以及SOFA评分升高与预后不良相关，而RAAA修复后3天HLA-DR表达水平降低。
Mortality from ruptured abdominal aortic aneurysms (RAAA) remains high. Severe systemic inflammation, leading to multi-organ failure, often occurs in these patients. In this study we describe the level of HLA-DR expression in a consecutive group of patients following surgery for RAAA and compare results between survivors and non-survivors. A similar comparison is made for IL-6 and IL-10 levels and Sequential Organ Failure Assessment (SOFA) scores. This is a prospective observational study. Patients with RAAA were prospectively analysed. Blood samples were collected on days 1, 3, 5, 7, 10 and 14. The fraction of CD-14 positive monocytes expressing HLA-DR was measured by flow-cytometry. IL-6 and IL-10 levels were measured by ELISA. The study included 30 patients with a median age of 70 years, of which 27 (90%) were men. Six patients died from multiple organ failure, all other patients survived. The SOFA scores were significantly higher in non-survivors on days 1 through 14. HLA-DR expression on monocytes was significantly lower on days 3, 5, 7, 10 and 14 in non-survivors. IL-6 and IL-10 levels were significantly higher in non-survivors on day 1 and days 1 and 3, respectively. HLA-DR expression on monocytes was decreased, especially in non-survivors. All patients with RAAA displayed a severe inflammatory and anti-inflammatory response with an increased production of IL-6 and IL-10. Poor outcome is associated with high levels of IL-6 and IL-10 and a high SOFA score in the first three days after surgery, while low levels of HLA-DR expression are observed from day three after RAAA repair.
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影响因子：
168.9
作者：
Jensen, LS;KissmeyerNielsen, P;Qvist, N
通讯作者：
Qvist, N
影响因子：
158.5
作者：
Blankensteijn, JD;de Jong, SECA;Grobbee, DE
通讯作者：
Grobbee, DE
影响因子：
4.3
作者：
Dueck, AD;Kucey, DS;Laupacis, A
通讯作者：
Laupacis, A
影响因子：
4.4
作者：
Monneret, G;Finck, ME;Lepape, A
通讯作者：
Lepape, A
影响因子：
168.9
作者：
Greenhalgh, RM;Brown, LC;Thompson, SG
通讯作者：
Thompson, SG