The soy isoflavones for reducing bone loss study: 3-yr effects on pQCT bone mineral density and strength measures in postmenopausal women.
The soy isoflavones for reducing bone loss study: 3-yr effects on pQCT bone mineral density and strength measures in postmenopausal women.
复制标题
DOI：
10.1016/j.jocd.2010.11.003
复制
发表时间：
2011-01
影响因子：
2.5
通讯作者：
Van Loan, Marta D.
中科院分区：
文献类型：
--
作者：
Shedd-Wise, Kristine M.;Alekel, D. Lee;Hofmann, Heike;Hanson, Kathy B.;Schiferl, Dan J.;Hanson, Laura N.;Van Loan, Marta D.
关键词：
大豆异黄酮发挥着不一致的骨密度保护作用，但在人类中的骨强度保护作用尚不清楚。我们的双盲随机对照试验检测了两种剂量(80或120 mg/d)的大豆异黄酮片与安慰剂片对健康绝经后妇女(46-63岁)的体积骨密度(VBMD)和强度(通过外周定量计算机断层扫描)的影响。测量股骨中段1/3处(N=171)和胫骨下端4%处骨小梁(TB)骨密度、骨皮质厚度(CtThk)、骨膜周长(PC)、骨膜周长(EC)和强度应变指数(SSI)的3年变化。我们没有发现对股骨CtThk、PC或EC，或胫骨TbBMD或PC的治疗效果。对胫骨TbBMD、SSI和股骨CtBMD的预测最强(负)的是时间点和骨吸收；全身脂肪质量对SSI有保护作用。随着末次月经开始时间的延长(p=0.012)，120 mg/d对CtBMD有保护作用。股骨SSI的最强预测因子是时间点、骨吸收和TLMP(保护性)。异黄酮片是SSI的负面预测因素，但80 mg/d随骨转换增加而具有保护作用(p=0.011)。大豆异黄酮治疗3年后，随着TLMP的增加，股骨中段的vBMD略有增加，随着骨转换的增加，股骨中段的SSI也有一定的改善。
Soy isoflavones exert inconsistent bone density-preserving effects, but the bone strength-preserving effects in humans are unknown. Our double-blind randomized controlled trial examined two soy isoflavone doses (80 or 120 mg/d) vs placebo tablets on volumetric bone mineral density (vBMD) and strength (via peripheral quantitative computed tomography) in healthy postmenopausal women (46–63 y). We measured 3 y change in cortical (Ct) BMD, cortical thickness (CtThk), periosteal circumference (PC), endosteal circumference (EC), and strength-strain index (SSI) at 1/3 midshaft femur (N=171) and trabecular (Tb) BMD, PC, and SSI at 4% distal tibia (N=162). We found no treatment effect on femur CtThk, PC, or EC, or tibia TbBMD or PC. Strongest predictors (negative) of tibia TbBMD and SSI and femur CtBMD were timepoint and bone resorption; whole body fat mass was protective of SSI. As time since last menstrual period (TLMP) increased (p=0.012), 120 mg/d was protective of CtBMD. Strongest predictors of femur SSI were timepoint, bone resorption, and TLMP (protective). Isoflavone tablets were negative predictors of SSI, but 80 mg/d became protective as bone turnover increased (p=0.011). Soy isoflavone treatment for 3 y was modestly beneficial for midshaft femur vBMD as TLMP increased, and for midshaft femur SSI as bone turnover increased.
登录
查看更多内容
DOI：
10.1093/rheumatology/ken177
发表时间：
2008-07
期刊：
Rheumatology (Oxford, England)
影响因子：
--
作者：
Seeman E
通讯作者：
Seeman E
影响因子：
7.1
作者：
Kenny, Anne M.;Mangano, Kelsey M.;Kerstetter, Jane E.
通讯作者：
Kerstetter, Jane E.
影响因子：
4.1
作者：
Devareddy, Latha;Khalil, Dania A.;Arjmandi, Bahram H.
通讯作者：
Arjmandi, Bahram H.
影响因子：
4.8
作者：
Kuiper, GGJM;Lemmen, JG;Gustafsson, JÄ
通讯作者：
Gustafsson, JÄ
影响因子：
7.1
作者：
Wong, William W.;Lewis, Richard D.;Smith, E. O'Brian
通讯作者：
Smith, E. O'Brian