Differential activation of the visual word form area during auditory phoneme perception in youth with dyslexia.
Differential activation of the visual word form area during auditory phoneme perception in youth with dyslexia.
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DOI：
10.1016/j.neuropsychologia.2020.107543
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发表时间：
2020-09
期刊：
影响因子：
2.6
通讯作者：
Binder JR
中科院分区：
文献类型：
--
作者：
Conant LL;Liebenthal E;Desai A;Seidenberg MS;Binder JR
发展性阅读障碍是一种学习障碍，其特征是难以准确和/或流畅地阅读单词。一些行为研究表明，在音素处理的早期阶段存在异常，当语音信号中的复杂的spectrotemporal模式进行分析，并分配到音素类别。在这项研究中，功能磁共振成像被用来比较与言语音节（P）和声学匹配的非音素刺激（N）在儿童和青少年阅读障碍和典型发展（TD）控制，年龄在8-17岁的分类歧视的大脑反应。TD组显示出显着更大的激活过程中的P条件相对于N在左腹侧枕颞叶皮层，以及对应的区域被称为“视觉词形区”（VWFA）。在整个参与者组中使用阅读表现作为连续变量的回归分析得出了类似的结果。总的来说，这些发现与先前的神经成像研究一致，这些研究使用印刷刺激在患有阅读障碍的个体中发现左侧枕颞区的激活减少;然而，目前的研究表明，在阅读过程中看到的这些激活差异在患有阅读障碍的青少年的听觉音素辨别过程中是明显的，这表明，在至少一个子集的儿童的主要缺陷可能在于早期的语音处理流和分类知觉可能是一个重要的目标，早期干预的儿童在阅读障碍的风险。
Developmental dyslexia is a learning disorder characterized by difficulties reading words accurately and/or fluently. Several behavioral studies have suggested the presence of anomalies at an early stage of phoneme processing, when the complex spectrotemporal patterns in the speech signal are analyzed and assigned to phonemic categories. In this study, fMRI was used to compare brain responses associated with categorical discrimination of speech syllables (P) and acoustically matched nonphonemic stimuli (N) in children and adolescents with dyslexia and in typically developing (TD) controls, aged 8–17 years. The TD group showed significantly greater activation during the P condition relative to N in an area of the left ventral occipitotemporal cortex that corresponds well with the region referred to as the “visual word form area” (VWFA). Regression analyses using reading performance as a continuous variable across the full group of participants yielded similar results. Overall, the findings are consistent with those of previous neuroimaging studies using print stimuli in individuals with dyslexia that found reduced activation in left occipitotemporal regions; however, the current study shows that these activation differences seen during reading are apparent during auditory phoneme discrimination in youth with dyslexia, suggesting that the primary deficit in at least a subset of children may lie early in the speech processing stream and that categorical perception may be an important target of early intervention in children at risk for dyslexia.
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DOI：
10.1080/713755750
发表时间：
1998-02-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION A-HUMAN EXPERIMENTAL PSYCHOLOGY
影响因子：
--
作者：
Adlard, A;Hazan, V
通讯作者：
Hazan, V
影响因子：
14.5
作者：
Clark, Kristi A.;Helland, Turid;Hugdahl, Kenneth
通讯作者：
Hugdahl, Kenneth
影响因子：
2.5
作者：
Brown, Steven;Laird, Angela R.;Pfordresher, Peter Q.;Thelen, Sarah M.;Turkeltaub, Peter;Liotti, Mario
通讯作者：
Liotti, Mario
影响因子：
2.6
作者：
Bogliotti, C.;Serniclaes, W.;Sprenger-CharolleS, L.
通讯作者：
Sprenger-CharolleS, L.
语音感知及其与中学和中学儿童中阅读发展的关系。
影响因子：
5.7
作者：
Conant LL;Liebenthal E;Desai A;Binder JR
通讯作者：
Binder JR