Transplantation of pancreatic islets.
Transplantation of pancreatic islets.
复制标题
胰岛移植。
DOI：
10.1146/annurev.iy.02.040184.001151
复制
发表时间：
1984
影响因子：
29.7
通讯作者：
J. Davie
中科院分区：
文献类型：
--
作者：
P. Lacy;J. Davie
糖尿病的并发症是在多年后发展起来的。它们累及眼睛、肾脏和心血管系统，并可能导致失明、肾功能衰竭和早期动脉硬化。显然，这些并发症是糖尿病状态的次要症状，是由于我们目前的治疗形式无法始终将血糖维持在正常范围内。胰岛素依赖型糖尿病患者胰岛中的胰岛素分泌细胞(β细胞)已被破坏或改变，其机制尚不清楚。因此，一种可能的治疗方法是将正常的胰岛移植到糖尿病患者体内，希望移植的胰岛能够保持正常的血糖，防止或阻止糖尿病并发症的发展。这种方法要求胰岛移植的排斥反应可以通过持续免疫抑制治疗以外的其他方法来预防。在过去的几年中，已经开发了几种方法来防止大鼠和小鼠的胰岛移植和异种移植的排斥反应，而不需要对受体动物进行持续的免疫抑制。在这篇综述中，我们描述了用同种异体移植物建立的胰岛移植模型，用于预防胰岛排斥反应的概念和程序，以及胰岛移植作为一种可能的人类糖尿病治疗方法的现状。
The complications in diabetes mellitus develop over many years. They involve the eye, kidney, and cardiovascular system and may lead to blindness, renal failure, and early development of arteriosclerosis. Apparently these compli cations are secondary to the diabetic state and are due to the inability of our present forms of therapy to maintain the blood sugar within normal limits at all times. The insulin-producing cells (beta cells) in the islets of Langerhans of insulin-dependent diabetics have either been destroyed or altered by mech anisms unknown at present. Thus, a possible therapeutic approach would be to transplant normal islets into diabetic patients with the hope that the trans plants would maintain normoglycemia and prevent or arrest the development of diabetic complications. This approach requires that rejection of the islet transplants be prevented by procedures other than continuous immunosup pressive therapy. During the past few years, several procedures have been developed that prevent rejection of islet allografts and xenografts in rats and mice without requiring continuous immunosuppression of the recipient animals. In this review we describe the islet transplant model as developed with isografts, the concepts and procedures used for prevention of islet rejection, and the present status of islet transplantation as a possible therapeutic approach to human diabetes.
影响因子：
6.2
作者：
Zitron,IM;Lacy,PE;Davie,JM
通讯作者：
Davie,JM
展示了朗格汉斯同种异体移植物维持已建立胰岛的主动耐受性。
DOI：
10.1073/pnas.79.13.4153
发表时间：
1982
影响因子：
11.1
作者：
Faustman,D;Hauptfeld,V;Lacy,P;Davie,J
通讯作者：
Davie,J
已建立抗 Ia 处理的同种异体胰岛移植物的小鼠缺乏供体特异性耐受性。
影响因子：
6.2
作者：
Morrow,CE;Sutherland,DE;Steffes,MW;Najarian,JS;Bach,FH
通讯作者：
Bach,FH