Integrative microphysiological tissue systems of cancer metastasis to the liver.
Integrative microphysiological tissue systems of cancer metastasis to the liver.
复制标题
癌症肝转移的整合微生理组织系统。
DOI：
10.1016/j.semcancer.2020.06.010
复制
发表时间：
2021-06
影响因子：
14.5
通讯作者：
Wells A
中科院分区：
文献类型：
--
作者：
Clark AM;Allbritton NL;Wells A
肝脏是各种实体肿瘤转移最常见的器官。生物和细胞复杂的肝组织系统的使用表明，肿瘤细胞的行为和治疗反应在肝脏微环境中受到调节，并且以不同于原发灶行为的方式进行调节。这些微生理系统为转移的肿瘤细胞生物学提供了意想不到的和强大的见解。然而，肿瘤和肝脏都不存在于孤立的组织中，必须在整个身体内发挥作用，并与其他器官一样对全身事件做出反应。为了检查一个器官对其他组织功能的影响，微生理系统正在联系在一起。在这里，我们讨论通过整合原发肿瘤和肝转移环境的复杂模型，将这一概念扩展到肿瘤转移。此外，炎症器官和免疫系统可以被结合到这些多器官系统中，以探索对肿瘤行为和癌症治疗的影响。
The liver is the most commonly involved organ in metastases from a wide variety of solid tumors. The use of biologically and cellularly complex liver tissue systems have shown that tumor cell behavior and therapeutic responses are modulated within the liver microenvironment and in ways distinct from the behaviors in the primary locations. These microphysiological systems have provided unexpected and powerful insights into the tumor cell biology of metastasis. However, neither the tumor nor the liver exist in an isolated tissue situation, having to function within a complete body and respond to systemic events as well as those in other organs. To examine the influence of one organ on the function of other tissues, microphysiological systems are being linked. Herein, we discuss extending this concept to tumor metastases by integrating complex models of the primary tumor with the liver metastatic environment. In addition, inflammatory organs and the immune system can be incorporated into these multi-organ systems to probe the effects on tumor behavior and cancer treatments.
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DOI：
10.1016/j.mattod.2015.05.002
发表时间：
2015-12
期刊：
Materials today (Kidlington, England)
影响因子：
--
作者：
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通讯作者：
Demirci U
影响因子：
5.6
作者：
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通讯作者：
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DOI：
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发表时间：
2017-12-28
期刊：
Aging
影响因子：
--
作者：
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通讯作者：
Mirnezami AH
DOI：
10.1177/1535370216658144
发表时间：
2016-09
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Clark AM;Ma B;Taylor DL;Griffith L;Wells A
通讯作者：
Wells A
影响因子：
8.8
作者：
通讯作者：
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