Silent trace eliminates differential eyeblink learning in abstinent alcoholics.

Silent trace eliminates differential eyeblink learning in abstinent alcoholics.
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DOI:
10.3390/ijerph6072007
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发表时间:
2009-07
影响因子:
--
通讯作者:
McGlinchey RE
McGlinchey RE
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Fortier CB;Maksimovskiy AL;Venne JR;LaFleche G;McGlinchey RE

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慢性酒精中毒对大脑有深远的影响,包括眨眼经典条件反射(EBCC)关键区域的体积减少。本研究采用延迟(n = 20)和微量(n = 17)辨别/逆转EBCC对戒酒者进行了挑战。比较结果显示,在逆转过程中,延迟和跟踪条件反射表现之间存在显著差异(t(35)= 2.08,p < 0.05)。两项任务之间的差异不显著(p = 0.44)。这些数据支持的概念,酗酒者越来越受损的复杂任务,扭转以前学到的歧视时,一个沉默的跟踪间隔。酗酒者在灵活改变习得性联想方面的障碍可能是他们持续成瘾的核心原因。
Chronic alcoholism has profound effects on the brain, including volume reductions in regions critical for eyeblink classical conditioning (EBCC). The current study challenged abstinent alcoholics using delay (n = 20) and trace (n = 17) discrimination/reversal EBCC. Comparisons revealed a significant difference between delay and trace conditioning performance during reversal (t (35) = 2.08, p < 0.05). The difference between the two tasks for discrimination was not significant (p = 0.44). These data support the notion that alcoholics are increasingly impaired in the complex task of reversing a previously learned discrimination when a silent trace interval is introduced. Alcoholics’ impairment in flexibly altering learned associations may be central to their continued addiction.
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发表时间: 2002-04-01
影响因子: 3.2
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