The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma.
The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma.
复制标题
作者：
散发性伯基特淋巴瘤（sBL）可以通过非常均一的mRNA表达特征从弥漫性大B细胞淋巴瘤（DLBCL）中区分出来。然而，目前尚不清楚是否所有三种BL变体FsBL，地方性BL（eBL）和人类免疫缺陷病毒相关BL（HIV-BL）F代表一个统一的生物实体，尽管它们在地理分布，与免疫缺陷和/或EB病毒（EBV）感染的发病率的差异。为了解决这个问题，我们从18例eBL、31例sBL和15例HIV-BL病例中生成了microRNA（miRNA）谱。此外，我们分析了86个DLBCL的miRNA表达，以确定miRNA谱是否概括了由mRNA谱证明的BL和DLBCL之间的分子差异。获得了区分BL和DLBCL的38个miRNAs的签名，这些miRNAs含有MYC调节的和核因子-kB通路相关的miRNAs。sBL和eBL的miRNA谱仅显示6个差异表达的miRNA，而HIV和EBV感染对BL的miRNA谱没有影响。总之，miRNA分析证实BL和DLBCL代表不同的淋巴瘤类别，并证明三种BL变体代表相同的生物实体，eBL和sBL之间只有边缘miRNA表达差异。
Sporadic Burkitt lymphoma (sBL) can be delineated from diffuse large B-cell lymphoma (DLBCL) by a very homogeneous mRNA expression signature. However, it remained unclear whether all three BL variantsFsBL, endemic BL (eBL) and human immunodeficiency virus-associated BL (HIV-BL)F represent a uniform biological entity despite their differences in geographical occurrence, association with immunodeficiency and/or incidence of Epstein-Barr virus (EBV) infection. To address this issue, we generated micro RNA (miRNA) profiles from 18 eBL, 31 sBL and 15 HIV-BL cases. In addition, we analyzed the miRNA expression of 86 DLBCL to determine whether miRNA profiles recapitulate the molecular differences between BL and DLBCL evidenced by mRNA profiling. A signature of 38 miRNAs containing MYC regulated and nuclear factor-kB pathway-associated miRNAs was obtained that differentiated BL from DLBCL. The miRNA profiles of sBL and eBL displayed only six differentially expressed miRNAs, whereas HIV and EBV infection had no impact on the miRNA profile of BL. In conclusion, miRNA profiling confirms that BL and DLBCL represent distinct lymphoma categories and demonstrates that the three BL variants are representatives of the same biological entity with only marginal miRNA expression differences between eBL and sBL.
登录
查看更多内容
影响因子：
12.3
作者：
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者：
Zhang J
影响因子：
8
作者：
Kluiver, J.;van den Berg, A.;Kroesen, B-J
通讯作者：
Kroesen, B-J
影响因子：
64.8
作者：
Alizadeh, AA;Eisen, MB;Staudt, LM
通讯作者：
Staudt, LM
影响因子：
158.5
作者：
Dave, Sandeep S.;Fu, Kai;Staudt, Louis M.
通讯作者：
Staudt, Louis M.
影响因子：
11.2
作者：
Iorio, MV;Ferracin, M;Croce, CM
通讯作者：
Croce, CM