Triglyceride Metabolism in the Liver.
Triglyceride Metabolism in the Liver.
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DOI：
10.1002/cphy.c170012
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发表时间：
2017-12-12
影响因子：
5.8
通讯作者：
Cohen DE
中科院分区：
文献类型：
--
作者：
Alves-Bezerra M;Cohen DE
甘油三酯分子代表脂肪酸在细胞内和血浆中的主要储存和运输形式。肝脏是脂肪酸代谢的中心器官。脂肪酸通过肝细胞从血浆中摄取和从头生物合成在肝脏中积累。脂肪酸通过细胞内的氧化或通过富含磷脂酰肌醇的极低密度脂蛋白分泌到血浆中而消除。尽管通过这些途径的流量很高，但在正常情况下，肝脏仅储存少量的脂肪酸作为甘油三酯。在营养过剩和肥胖的情况下，肝脏脂肪酸代谢发生改变，通常导致肝细胞内甘油三酯的积累，并导致称为非酒精性脂肪性肝病（NAFLD）的临床病症。在这篇综述中，我们描述了目前对肝脏中脂肪酸和甘油三酯代谢及其在健康和疾病中的调节的理解，确定了未来研究的潜在方向。了解肝脏脂肪蓄积的分子机制对于NAFLD靶向治疗的发展至关重要。
Triglyceride molecules represent the major form of storage and transport of fatty acids within cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids accrue in liver by hepatocellular uptake from the plasma and by de novo biosynthesis. Fatty acids are eliminated by oxidation within the cell or by secretion into the plasma within triglyceride-rich very low density lipoproteins. Notwithstanding high fluxes through these pathways, under normal circumstances the liver stores only small amounts of fatty acids as triglycerides. In the setting of overnutrition and obesity, hepatic fatty acid metabolism is altered, commonly leading the accumulation of triglycerides within hepatocytes, and to a clinical condition known as non-alcoholic fatty liver disease (NAFLD). In this review, we describe the current understanding of fatty acid and triglyceride metabolism in the liver and its regulation in health and disease, identifying potential directions for future research. Advances in understanding the molecular mechanisms underlying the hepatic fat accumulation are critical to the development of targeted therapies for NAFLD.
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DOI：
10.1016/j.jnutbio.2010.01.005
发表时间：
2010-11
期刊：
The Journal of nutritional biochemistry
影响因子：
--
作者：
Atshaves BP;Martin GG;Hostetler HA;McIntosh AL;Kier AB;Schroeder F
通讯作者：
Schroeder F
影响因子：
7.7
作者：
Bell, Ming;Wang, Hong;Chen, Hui;McLenithan, John C.;Gong, Da-Wei;Yang, Rong-Zee;Yu, Daozhan;Fried, Susan K.;Quon, Michael J.;Londos, Constantine;Sztalryd, Carole
通讯作者：
Sztalryd, Carole
影响因子：
13.5
作者：
Birkenfeld, Andreas L.;Shulman, Gerald I.
通讯作者：
Shulman, Gerald I.
影响因子：
4.1
作者：
BRADY, LJ;BRADY, PS;HOPPEL, CL
通讯作者：
HOPPEL, CL
影响因子：
4.8
作者：
Abo-Hashema, KAH;Cake, MH;Clarke, D
通讯作者：
Clarke, D