A simultaneous evaluation of multiple markers of ethanol/placebo challenges in sons of alcoholics and controls.
A simultaneous evaluation of multiple markers of ethanol/placebo challenges in sons of alcoholics and controls.
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同时评估酗酒者和对照组的儿子的乙醇/安慰剂挑战的多种标志物。
DOI：
10.1001/archpsyc.1988.01800270019002
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发表时间：
1988
影响因子：
--
通讯作者：
E. Gold
中科院分区：
文献类型：
--
作者：
M. Schuckit;E. Gold
这项研究评估了30名酗酒父亲的儿子和30名没有已知酗酒亲属的匹配对照组对两种剂量的乙醇(0.75和1.1毫升/公斤)的多方面反应。根据先前的研究结果，评估包括酒精后主观感觉的变化，身体摇摆或静止性共济失调的水平，以及血浆催乳素和皮质醇的水平。对60名男性样本的逐步判别函数分析表明，四项指标(高剂量后最大主观感受、高剂量后两个时间点的皮质醇水平和低剂量后的催乳素结果)相结合，可正确识别83%的对照组和70%的酗酒者儿子。这包括判别分数为+1或-1且被认为是可靠分类的每一组中约40%的人。这些结果在折叠式验证过程中相对稳健。使用主成分分析在乙醇后测试分数集群中寻找独立因素的结果与判别分析一致，表明乙醇反应的三个重叠区域的可能性，包括高剂量乙醇挑战后的主观感受(解释46%的方差)，高剂量乙醇后的激素变化以及身体摇摆项目(14%的方差)，以及低剂量乙醇后的催乳素变化(9%的方差)。被正确归类和不正确归类的男性之间的背景差异很小。
This study evaluates multiple aspects of the reaction to two doses of ethanol (0.75 and 1.1 mL/kg) in 30 sons of alcoholic fathers and 30 matched controls with no known alcoholic relatives. Based on results of prior research, the evaluations included the postethanol changes in subjective feelings, levels of body sway or static ataxia, and plasma levels of prolactin and cortisol. A stepwise discriminant function analysis on the sample of 60 men revealed that four items (maximum terrible subjective feelings after high dose, cortisol values at two time points after high dose, and prolactin results after low dose) combined to correctly identify 83% of the controls and 70% of the sons of alcoholics. This included approximately 40% of each group whose discriminant scores were +1 or -1 and who were considered to be solidly classified. These results were relatively robust on a jackknife validation procedure. Results of a search for independent factors in the cluster of test scores after ethanol using a principal components analysis were consistent with the discriminant analysis, indicating the possibility of three overlapping domains of the ethanol response, including subjective feelings after the high-dose ethanol challenge (explaining 46% of the variance), hormonal changes after high-dose ethanol along with body sway items (14% of variance), and prolactin changes after low-dose ethanol (9% of variance). There were few background differences between men who had been properly and improperly classified.
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影响因子：
56.9
作者：
CLONINGER, CR
通讯作者：
CLONINGER, CR
酗酒者的儿子和对照受试者的血清催乳素水平。
DOI：
10.1176/ajp.144.7.854
发表时间：
1987
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Schuckit,MA;Gold,E;Risch,C
通讯作者：
Risch,C
酗酒者和对照组的亲属摄入乙醇后血浆皮质醇的差异：初步结果。
DOI：
--
发表时间：
1984
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Schuckit,MA
通讯作者：
Schuckit,MA
影响因子：
--
作者：
Bohman,M;Sigvardsson,S;Cloninger,CR
通讯作者：
Cloninger,CR
酗酒者和对照组的儿子服用乙醇后的血浆皮质醇水平。
影响因子：
--
作者：
Schuckit,MA;Gold,E;Risch,C
通讯作者：
Risch,C