8;21 translocation in acute granulocytic leukaemia: cytological, cytochemical and clinical features-猫眼课题宝

急性粒细胞白血病的 8;21 易位：细胞学、细胞化学和临床特征

DOI：

发表时间：

1984

期刊：

British Journal of Haematology

影响因子：

6.5

通讯作者：

中科院分区：

医学2区

文献类型：

作者：

D. Swirsky;Y. S. Li;J. Matthews;R. Flemans;J. Rees;F. Hayhoe

概括。对 30 名 8;21 易位患者和 3 名具有密切相关变异的患者进行了研究。年龄范围为 3 至 64 岁（平均 28±3）。 31 例患者参加了 MRC 的第八次急性髓系白血病试验。二十九人 (88%) 获得完全缓解。大多数患者的骨髓涂片显示具有特征性异常的粒细胞成熟（M2，FAB 分类），但至少有 6 名患者主要显示成粒细胞（M1）形态。母细胞在大小和核质比例方面存在明显异质性。使用苏丹黑 B 和二氨基联苯胺过氧化物酶染色剂在母细胞中观察到典型的染色模式，并在较小程度上使用高碘酸-希夫和氯乙酸酯酶染色剂观察到典型的染色模式。所有病例中丁酸酯酶均为阴性。 31 例中粒细胞前体中存在 Auer 杆，2 例中嗜酸性粒细胞前体中存在 Auer 杆。在大多数情况下，易位的存在是根据细胞学和细胞化学结果预测的。七名患者出现固体白血病沉积物，主要位于乳突腔、眼眶腔或胸椎（硬膜外）。

Summary. Thirty patients with the 8;21 translocation and three with closely related variants have been studied. Ages ranged from 3 to 64 years (mean 28±3). Thirty‐one were entered into the MRC's 8th Acute Myeloid Leukaemia Trial. Twenty‐nine (88%) achieved complete remission. Marrow smears from most patients showed granulocytic maturation (M2, FAB classification) with characteristic abnormalities, but at least six showed predominantly myeloblastic (M1) morphology. The blast cells were markedly heterogeneous with regard to size and nuclear cytoplasmic ratio. Typical staining patterns were observed in the blast cells using Sudan black B and diaminobenzidine peroxidase stains, and to a lesser extent with periodic acid‐Schiff and chloroacetate esterase. Butyrate esterase was negative in all cases. Auer rods were present in the granulocyte precursors in 31 cases and in eosinophil precursors in two cases. In most cases the existence of the translocation was predicted from the cytological and cytochemical findings. Seven patients developed solid leukaemic deposits, principally in the mastoid cavities, orbital cavities or thoracic spine (extradural).

Two human c-onc genes are located on the long arm of chromosome 8.