The Alisma and Rhizoma decoction abates nonalcoholic steatohepatitis-associated liver injuries in mice by modulating oxidative stress and autophagy
The Alisma and Rhizoma decoction abates nonalcoholic steatohepatitis-associated liver injuries in mice by modulating oxidative stress and autophagy
复制标题
泽泻和根茎汤通过调节氧化应激和自噬减轻小鼠非酒精性脂肪性肝炎相关的肝损伤
DOI：
10.1186/s12906-019-2488-6
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发表时间：
2019-04
影响因子：
--
通讯作者：
Jiang Yuanye
中科院分区：
文献类型：
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作者：
Jing Menghui;Xu Lijun;Yang Lijuan;Jin Lei;Gong Peiqiang;Lu Juan;Lin Hui;Wang Jinping;Cao Qin;Jiang Yuanye
BackgroundTo investigate the effects of the Alisma and Rhizoma decoction on nonalcoholic steatohepatitis (NASH) and to further shed light on the underlying mechanisms of the actions of the Alisma and Rhizoma decoction.MethodsPlasma alanine aminotransferase (ALT) content was determined and liver inflammation and fibrosis were evaluated. Intrahepatocellular malondialdehyde and superoxide dismutase contents were determined using commercially available kits Furthermore, α-SMA expression in liver tissues was examined by immunohistochemistry and LC3-II was detected by immunoblotting assays.ResultsMice receiving the Alisma and Rhizoma decoction by gastric lavage had significantly lower plasma ALT content and markedly higher hepatic superoxide dismutase activity than mice receiving the methionine-choline deficient (MCD) diet. Furthermore, the decoction aborted MCD-induced increase in liver malondialdehyde content. Immunohistochemistry showed that the decoction suppressed hepatic α-SMA expression. Our transmission electronic microscopy revealed that the decoction markedly reduced the number of autophagosomes and immunoblotting assays showed that the decoction caused a dose-dependent decrease in LC3-II in hepatic tissues.Conclusion
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DOI：
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发表时间：
--
期刊：
--
影响因子：
--
作者：
A. Gusdon;Ke-xiu Song;S. Qu;Liang-Jun Yan
通讯作者：
A. Gusdon;Ke-xiu Song;S. Qu;Liang-Jun Yan
影响因子：
3.7
作者：
Thomas, Fancy C.;Taskar, Kunal;Rudraraju, Vinay;Goda, Satyanarayana;Thorsheim, Helen R.;Gaasch, Julie A.;Mittapalli, Rajendar K.;Palmieri, Diane;Steeg, Patricia S.;Lockman, Paul R.;Smith, Quentin R.
通讯作者：
Smith, Quentin R.
影响因子：
5.6
作者：
Nassir F;Ibdah JA
通讯作者：
Ibdah JA
泽泻：重要中药的民族药理学、植物化学和药理学
影响因子：
5.7
作者：
Shu, Zhiheng;Pu, Jiang;Zheng, Chengjian
通讯作者：
Zheng, Chengjian
影响因子：
13.5
作者：
Wree, Alexander;Eguchi, Akiko;McGeough, Matthew D.;Pena, Carla A.;Johnson, Casey D.;Canbay, Ali;Hoffman, Hal M.;Feldstein, Ariel E.
通讯作者：
Feldstein, Ariel E.