Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation.
Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation.
复制标题
DOI：
10.1093/nar/gkp1176
复制
发表时间：
2010-05
影响因子：
14.9
通讯作者：
Vagner S
中科院分区：
文献类型：
--
作者：
Millevoi S;Vagner S
Messenger RNA（mRNA）3'末端形成是一个核过程，所有真核原代转录本均裂解，其中大多数都获得了poly（a）尾巴。大型裂解/多腺苷酸化机制在基因表达中起关键作用，成熟mRNA的尾巴对其功能至关重要，包括稳定性，易位到细胞质和翻译。在转录单元中选择单个或替代poly（a）信号。这一过程并在此处调节其与其他核事件的相互作用，我们回顾了真核3'结束加工机以及一系列全面的调节因素，并通过提出几种重叠模型来讨论3'端处理调节的不同分子机制规定。
Messenger RNA (mRNA) 3′ end formation is a nuclear process through which all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a poly(A) tail. This process, which consists in the recognition of defined poly(A) signals of the pre-mRNAs by a large cleavage/polyadenylation machinery, plays a critical role in gene expression. Indeed, the poly(A) tail of a mature mRNA is essential for its functions, including stability, translocation to the cytoplasm and translation. In addition, this process serves as a bridge in the network connecting the different transcription, capping, splicing and export machineries. It also participates in the quantitative and qualitative regulation of gene expression in a variety of biological processes through the selection of single or alternative poly(A) signals in transcription units. A large number of protein factors associates with this machinery to regulate the efficiency and specificity of this process and to mediate its interaction with other nuclear events. Here, we review the eukaryotic 3′ end processing machineries as well as the comprehensive set of regulatory factors and discuss the different molecular mechanisms of 3′ end processing regulation by proposing several overlapping models of regulation.
登录
查看更多内容
影响因子：
14.9
作者：
Arhin, GK;Boots, M;Wilusz, J
通讯作者：
Wilusz, J
影响因子：
11.4
作者：
BIENROTH, S;KELLER, W;WAHLE, E
通讯作者：
WAHLE, E
影响因子：
14.9
作者：
Chen, F;Wilusz, J
通讯作者：
Wilusz, J
影响因子：
11.4
作者：
Chen, ZY;Li, YZ;Krug, RM
通讯作者：
Krug, RM
影响因子：
5.3
作者：
Castelo-Branco, P;Furger, A;Proudfoot, N
通讯作者：
Proudfoot, N