Effect of adjuvant-induced arthritis on hepatic drug metabolism in rats.
Effect of adjuvant-induced arthritis on hepatic drug metabolism in rats.
复制标题
佐剂诱导的关节炎对大鼠肝脏药物代谢的影响。
DOI：
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
H. Shimeno
中科院分区：
文献类型：
--
作者：
A. Toda;N. Ishii;T. Kihara;A. Nagamatsu;H. Shimeno
1. Hepatic drug metabolism was investigated in normal, adjuvant-induced arthritic (AA), indomethacin-treated AA and prednisolone-treated AA rats. The contents of P450 and b5 and the activities of NADH-b5 reductase (fp2), NADPH-ferrihaemoprotein reductase, P450 mixed function oxidase, FAD-monooxygenase and several enzymes involved in conjugation were remarkably lower in AA than in normal rats. 2. Many of the decreased enzyme activities were restored to normal levels by the continuous administration (3 weeks) of indomethacin or prednisolone, which improved the arthritic states of the animals. However, the restoration of FAD-monooxygenase activity by the administration of indomethacin or prednisolone was incomplete. The P450 and b5 contents and the fp2 activity in prednisolone-treated AA rats were also significantly lower than those in normal rats. 3. These findings indicate that the ability of the liver to metabolize drugs (both oxidation and conjugation) in AA rats is greatly decreased and that a long series of the treatment of AA rats with anti-inflammatory drugs is required to restore several enzyme activities.
大鼠肝细胞核膜的混合功能胺氧化酶。
影响因子：
5.8
作者：
Sum,CY;Kasper,CB
通讯作者：
Kasper,CB