Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area
Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area
复制标题
将催产素注射到海马腹侧下托，通过增加腹侧被盖区的谷氨酸能神经传递来诱导雄性大鼠阴茎勃起
DOI：
10.1016/j.neuropharm.2011.03.026
复制
发表时间：
2011
影响因子：
4.7
通讯作者：
M. R. Melis
中科院分区：
文献类型：
--
作者：
S. Succu;F. Sanna;A. Argiolas;M. R. Melis
将催产素（100 ng）单侧注射到海马腹侧下托中诱导阴茎勃起发作，该发作在治疗后30 min开始，并且通过预先将催产素受体拮抗剂d（CH 2）5 Tyr（Me）2-Orn 8-vasotocin（2 μg）注射到腹侧下托中而被消除。催产素诱导的阴茎勃起发生在15分钟后，细胞外多巴胺的浓度增加的透析液中获得的无论是从核腹侧或前边缘内侧前额叶皮层，这也被取消d（CH 2）5酪氨酸（Me）2-Orn 8-vasotocin。细胞外谷氨酸浓度的增加，也观察到在相同的透析液中获得的腹侧被盖区，但不是从前边缘内侧前额叶皮质或多巴胺浓度测定，15分钟后，催产素注射到腹侧下托核。这种作用也被取消的前注射d（CH 2）5 Tyr（Me）2-Orn 8-vasotocin到腹侧下托。这些结果证实了以前的研究结果表明，腹侧下托催产素诱导阴茎勃起介导的腹侧被盖区谷氨酸神经传递的增加。这反过来又增加了中边缘和中皮质多巴胺能活动，在伏隔核和边缘前内侧前额叶皮质中释放多巴胺。这些结果与以前的研究支持的假设，腹侧下托参与了一个复杂的神经回路控制不仅阴茎勃起和交配，但也性动机，唤醒和奖励。
Oxytocin (100 ng) injected unilaterally into the ventral subiculum of the hippocampus induces penile erection episodes, which started 30 min after treatment and were abolished by the prior injection of d(CH2)5Tyr(Me)2-Orn8-vasotocin (2 μg), an oxytocin receptor antagonist, into the ventral subiculum. Oxytocin-induced penile erection occurred 15 min after the increase of the concentration of extracellular dopamine in the dialysate obtained from either the nucleus accumbens or the prelimbic medial prefrontal cortex, which was also abolished by d(CH2)5Tyr(Me)2-Orn8-vasotocin. An increase in extracellular glutamic acid concentration was also observed in the same dialysate obtained from the ventral tegmental area, but not from the prelimbic medial prefrontal cortex or the nucleus accumbens in which dopamine concentration was measured, 15 min after the injection of oxytocin into the ventral subiculum. This effect was also abolished by the prior injection of d(CH2)5Tyr(Me)2-Orn8-vasotocin into the ventral subiculum. These results confirm previous findings showing that ventral subiculum oxytocin-induced penile erection is mediated by an increase of glutamic acid neurotransmission in the ventral tegmental area. This in turn increases mesolimbic and mesocortical dopaminergic activity, releasing dopamine in the nucleus accumbens and in the prelimbic medial prefrontal cortex. These results are in line with previous studies supporting the hypothesis that the ventral subiculum participates in a complex neural circuit controlling not only penile erection and copulation, but also sexual motivation, arousal and rewarding.
影响因子：
4.8
作者：
Vaccari, C;Lolait, SJ;Ostrowski, NL
通讯作者：
Ostrowski, NL
DOI：
10.1111/j.1399-3011.1980.tb02962.x
发表时间：
2009-01
期刊：
International journal of peptide and protein research
影响因子：
--
作者：
K. Bańkowski;M. Manning;J. Seto;J. Haldar;Wilbur H. Sawyer
通讯作者：
K. Bańkowski;M. Manning;J. Seto;J. Haldar;Wilbur H. Sawyer