Review of Curcumin Physicochemical Targeting Delivery System.
Review of Curcumin Physicochemical Targeting Delivery System.
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DOI：
10.2147/ijn.s276201
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发表时间：
2020
影响因子：
8
通讯作者：
Wei Y
中科院分区：
文献类型：
--
作者：
Li L;Zhang X;Pi C;Yang H;Zheng X;Zhao L;Wei Y
姜黄素（Curcumin，CUR）是从银杏科和天南星科植物根茎中提取的一种中药单体，具有抗肿瘤、抗炎、抗氧化、抗病毒、抗肝纤维化、抗动脉粥样硬化、抗阿尔茨海默病等多种药理活性。然而，一些问题显着影响其生物活性，如水溶性低，物理化学不稳定，生物利用度差，靶向效力低。为了进一步提高其疗效，许多高效的给药系统被开发出来。其中，物理化学靶向制剂可以改善CUR的性质、靶向能力和生物活性。因此，在这次审查中，CUR载体系统进行了讨论，这是由微环境的理化特性（如肿瘤组织的pH值变化），受外部影响，如磁场和车辆制定的热敏材料。
Curcumin (CUR), as a traditional Chinese medicine monomer extracted from the rhizomes of some plants in Ginkgo and Araceae, has shown a wide range of therapeutic and pharmacological activities such as anti-tumor, anti-inflammatory, anti-oxidation, anti-virus, anti-liver fibrosis, anti-atherosclerosis, and anti-Alzheimer’s disease. However, some issues significantly affect its biological activity, such as low aqueous solubility, physico-chemical instability, poor bioavailability, and low targeting efficacy. In order to further improve its curative effect, numerous efficient drug delivery systems have been carried out. Among them, physicochemical targeting preparations could improve the properties, targeting ability, and biological activity of CUR. Therefore, in this review, CUR carrier systems are discussed that are driven by physicochemical characteristics of the microenvironment (eg, pH variation of tumorous tissues), affected by external influences like magnetic fields and vehicles formulated with thermo-sensitive materials.
影响因子：
2.1
作者：
Mullally WJ;O'Súilleabháin CB;Brady C;O'Reilly S
通讯作者：
O'Reilly S