Effect of bariatric surgery on the metabolic syndrome: a population-based, long-term controlled study.
Effect of bariatric surgery on the metabolic syndrome: a population-based, long-term controlled study.
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DOI：
10.4065/83.8.897
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发表时间：
2008-08
影响因子：
8.9
通讯作者：
Lopez-Jimenez F
中科院分区：
文献类型：
--
作者：
Batsis JA;Romero-Corral A;Collazo-Clavell ML;Sarr MG;Somers VK;Lopez-Jimenez F
评估减肥手术减肥对代谢综合征（MetS）患病率的影响，并检查MetS消退的预测因素。我们在1990年1月1日至2003年12月31日期间对接受AHA/NHLBI定义的MetS（甘油三酯升高、高密度脂蛋白降低、血压升高、空腹血糖升高和肥胖指标）减肥手术的患者进行了一项基于人群的回顾性研究。有180例Roux-en-Y胃旁路术患者和157例非手术患者在减肥计划中进行了评估。我们确定了代谢综合征患病率的变化，并使用逻辑回归模型来确定代谢综合征消退的预测因素。平均随访时间为3.4年。手术组的所有MetS成分均得到改善，药物使用量减少。非手术患者的高密度脂蛋白有所改善。在180例手术患者中，MetS患病率从156例（87%）降至53例（29%），非手术组从133例（85%）降至117例（75%）。在随访时发生代谢综合征的减肥手术患者的相对风险降低0.59（95%CI 0.48-0.67; p<0.001）]。需要手术治疗以解决1例MetS病例的数量为2.1。在排除糖尿病或心血管疾病患者或使用非BMI MetS诊断标准后，结果相似。代谢综合征消退的重要预测因素包括超重减轻5%（OR 1.26; 95%CI 1.19-1.34;p<0.001）和糖尿病（OR 0.32; 95%CI 0.15-0.68;p=0.003）。Roux-en-Y胃旁路术诱导MetS患病率的显著和持续改善。我们的研究结果表明，MetS的可逆性更多地取决于多余的重量损失的量比其他参数。
To assess the effect of weight loss by bariatric surgery on metabolic syndrome (MetS) prevalence and to examine predictors of MetS resolution. We performed a population-based, retrospective study between January 1st,1990 and December 31st,2003 of patients evaluated for bariatric surgery with AHA/NHLBI-defined MetS (increased triglycerides, low high density lipoprotein, increased blood pressure, increased fasting glucose, and a measure of obesity). There were 180 Roux-en-Y gastric bypass patients and 157 non-operative patients assessed in a weight-reduction program. We determined the change in MetS prevalence and used logistic regression models to determine predictors of MetS resolution. Mean follow-up was 3.4 years. All MetS components improved in the surgical group and medication use decreased. Non-operative patients had improvements in high density lipoprotein. Of the 180 surgical patients, MetS prevalence decreased from 156 patients (87%) to 53 (29%), and from 133 patients (85%) to 117 (75%) in the non-operative group. There was a relative risk reduction of 0.59 (95% CI 0.48-0.67; p<0.001)] with bariatric surgery patients having MetS at follow-up. The number needed to treat with surgery to resolve one case of MetS was 2.1. Results were similar after excluding patients with diabetes or cardiovascular disease or after using non-BMI diagnostic criteria for MetS. Significant predictors of MetS resolution included a 5% loss in excess weight (OR 1.26; 95%CI 1.19-1.34;p<0.001) and diabetes (OR 0.32; 95%CI 0.15-0.68;p=0.003). Roux-en-Y gastric bypass induces considerable and persistent improvement in MetS prevalence. Our results suggest that reversibility of MetS depends more on the amount of excess weight lost than on other parameters.
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影响因子：
9
作者：
Christou, NV;Sampalis, JS;MacLean, LD
通讯作者：
MacLean, LD
影响因子：
16.2
作者：
Ekelund, U;Brage, S;Wareham, NJ
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Wareham, NJ
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作者：
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作者：
Carey, Daniel Gene;Pliego, German J.;Raymond, Robert L.
通讯作者：
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