Analysis of intracranial volume ratios by means of cerebrospinal fluid deployment indicators.
Analysis of intracranial volume ratios by means of cerebrospinal fluid deployment indicators.
复制标题
通过脑脊液部署指标分析颅内容积比。
作者：
E. Szczepek;L. Czerwosz;K. Nowinski;Z. Czernicki;J. Jurkiewicz
引言
成像研究不仅可以可视化大脑的总体结构，还可以精确测量脑组织体积和单个脑叶及其结构的大小。本研究的目的是测定颅内脑室系统的脑脊液(CSF)容量与脑组织体积的比率，以及蛛网膜下腔和基底池的脑脊液(CSF)容量与脑组织体积的比率。
材料和方法
对23例男性和女性(平均56.9±6.1岁)诊断为正常压力性脑积水(NPH)的男性和27例女性(平均70.6±5.2岁)脑萎缩(BA)患者进行了CT图像体积测量的评价。在CT成像研究中，收集的脑组织总体积和脑脊液体积被映射到彩色标尺上。使用VisNow软件进行容量评估。组间比较采用独立样本的非参数Kolmogorov-Smirnov检验(K-S)。配对资料比较采用非参数Wilcoxon检验。
结果
BA组和NPH组的脑体积(脑体积-BV)和脑脊液体积(液体体积-FV)差异均有统计学意义。SBR(蛛网膜下腔和基底池与脑的比率)和VBR(脑室与脑的比率)指标在NPH组和BA组之间差异显著且非常显著。NPH组VBR值明显高于BA组。BA组的SBR值高于NPH组。
结论
在50名患者的研究组中同时使用VBR和SBR两项指标，可以将NPH组和BA组完全分开。这种区分可以有真正的诊断价值。因此，基于头颅CT的脑脊液和脑组织体积的定量评估可以成为鉴别脑积水和脑萎缩的重要组成部分。
INTRODUCTION
Imaging studies make it possible not only to visualize the general structure of the brain but also to take precise measurements of brain tissue volume and the size of individual lobes and their structure. The aim of this study was to determine the ratio of cerebrospinal fluid (CSF) volume contained in the intracranial ventricular system to the brain tissue volume and the ratio of CSF volume in the subarachnoid space and basal cisterns to the brain tissue volume.
MATERIAL AND METHODS
The evaluation of volumetric measurements of computed tomographic (CT) images was undertaken on 23 male and female patients (average age 56.9 ± 6.1) diagnosed with normal pressure hydrocephalus (NPH) and 27 male and female patients (average age 70.6 ± 5.2) diagnosed with brain atrophy (BA). In the CT imaging studies, the total brain tissue volume and CSF volume collected in the intracranial fluid cavities were mapped to a colour scale. The VisNow software was used for volumetric evaluation. The groups were compared by means of the non-parametric Kolmogorov-Smirnov test (K-S) for independent samples. Paired data were compared by means of the nonparametric Wilcoxon test.
RESULTS
The volumes of brain (brain volume - BV) and cerebrospinal fluid (fluid volume - FV) differ greatly from each other in both groups BA and NPH. The SBR (subarachnoid space and basal cisterns-to-brain ratio) and VBR (ventricle-to-brain ratio) indicators differ significantly and very much within the NPH group as well as within the BA group. In the NPH group a clearly higher value of VBR can be observed in comparison with the BA group. There was a higher value of SBR in the BA than the NPH group.
CONCLUSIONS
The simultaneous use of two indicators, VBR and SBR, on a study group of 50 patients enabled the total separation of NPH and BA groups. This differentiation can have real diagnostic value. Thus the volumetric assessment of the volume of CSF and brain tissue based on CT of the head can become an important part of the differential diagnosis of hydrocephalus and brain atrophy.
影响因子：
11
作者：
Geroldi, C;Laakso, MP;Frisoni, GB
通讯作者：
Frisoni, GB