Pharmacokinetics of oseltamivir among pregnant and nonpregnant women.
Pharmacokinetics of oseltamivir among pregnant and nonpregnant women.
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DOI：
10.1016/j.ajog.2011.03.002
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发表时间：
2011-06
影响因子：
9.8
通讯作者：
Obstetric-Fetal Pharmacology Research Units Network
中科院分区：
文献类型：
--
作者：
Beigi RH;Han K;Venkataramanan R;Hankins GD;Clark S;Hebert MF;Easterling T;Zajicek A;Ren Z;Mattison DR;Caritis SN;Obstetric-Fetal Pharmacology Research Units Network
描述奥司他韦及其活性代谢物奥司他韦羧酸盐在妊娠期的药代动力学。妊娠的生理变化，包括肾滤过和分泌增加，可能会增加奥司他韦羧酸盐的清除率。入选了16名服用奥司他韦预防或治疗疑似/确诊流感感染的孕妇。23名未怀孕的育龄女性作为对照组。主要药代动力学终点是奥司他韦羧酸盐的血浆浓度-时间曲线下面积（AUC）。妊娠并不改变母体化合物奥司他韦的药代动力学参数。然而，与非妊娠女性相比，妊娠女性中羧酸奥司他韦的血浆浓度-时间曲线下面积（AUC）显著较低（p=0.007），表观清除率显著较高（p=0.006）。妊娠产生较低的全身水平的奥司他韦羧酸盐。在妊娠期间增加奥司他韦的剂量和/或给药频率可能是必要的，以使妊娠和非妊娠女性的暴露量相当。
To delineate the pharmacokinetics of oseltamivir and its active metabolite oseltamivir carboxylate during pregnancy. Physiologic changes of pregnancy, including increased renal filtration and secretion, may increase the clearance of oseltamivir carboxylate. Sixteen pregnant women taking oseltamivir for prophylaxis or treatment of suspected/proven influenza infection were enrolled. Twenty-three non-pregnant reproductive-age females served as the control group. The primary pharmacokinetic endpoint was area under the plasma concentration-time curve (AUC) for oseltamivir carboxylate. Pregnancy did not alter the pharmacokinetic parameters of the parent compound, oseltamivir. However, for oseltamivir carboxylate the area under the plasma concentration-time curve (AUC) was significantly lower (p=0.007) and the apparent clearance significantly higher (p=0.006) in pregnant women compared with non-pregnant women. Pregnancy produces lower systemic levels of oseltamivir carboxylate. Increasing the dose and/or dosing frequency of oseltamivir during pregnancy may be necessary in order to achieve comparable exposure in pregnant and non-pregnant women.
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DOI：
10.1016/0002-9378(58)90027-9
发表时间：
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影响因子：
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作者：
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