Immunogenetic factors affecting susceptibility of humans and rodents to hantaviruses and the clinical course of hantaviral disease in humans.
Immunogenetic factors affecting susceptibility of humans and rodents to hantaviruses and the clinical course of hantaviral disease in humans.
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DOI：
10.3390/v6052214
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发表时间：
2014-05-26
期刊：
影响因子：
--
通讯作者：
Vaheri A
中科院分区：
文献类型：
--
作者：
Charbonnel N;Pagès M;Sironen T;Henttonen H;Vapalahti O;Mustonen J;Vaheri A
我们回顾了免疫相关基因与人类和啮齿动物对汉坦病毒的易感性以及与人类汉坦病毒疾病严重程度的关系。几个I类和II类HLA单倍型与严重或良性汉坦病毒感染，这些单倍型不同的地方和汉坦病毒。其他免疫相关基因的多态性，包括C4 A基因和TNF基因的高产基因型，与严重PUUV感染相关。可能导致疾病或PUUV感染严重程度的其他基因包括不携带白细胞介素-1受体拮抗剂（IL-1 RA）等位基因2和IL-1β（-511）等位基因2、纤溶酶原激活物抑制剂（派-1）和血小板GP 1a多态性。此外，还进行了免疫遗传学研究，以确定可能与水库中汉坦病毒的持续存在/清除有关的机制。在实验感染期间，持续性与抗炎反应的上调相关。使用天然啮齿动物种群样品，分析了几种基因的多态性和/或表达水平。根据啮齿动物或人/汉坦病毒相互作用的文献（一些Mhc II类基因、Tnf启动子和编码蛋白质TLR 4、TLR 7、Mx2和β3整联蛋白的基因）选择这些基因。在欧洲取样的银行田鼠种群之间的遗传分化估计的比较，在中性和候选基因，已允许证据的选择TNF，MX2和Drb MHC II类基因的签名。总之，这些结果证实了啮齿动物耐受策略进化的假设。最后，我们从医学和流行病学的角度讨论了这些结果的重要性。
We reviewed the associations of immunity-related genes with susceptibility of humans and rodents to hantaviruses, and with severity of hantaviral diseases in humans. Several class I and class II HLA haplotypes were linked with severe or benign hantavirus infections, and these haplotypes varied among localities and hantaviruses. The polymorphism of other immunity-related genes including the C4A gene and a high-producing genotype of TNF gene associated with severe PUUV infection. Additional genes that may contribute to disease or to PUUV infection severity include non-carriage of the interleukin-1 receptor antagonist (IL-1RA) allele 2 and IL-1β (-511) allele 2, polymorphisms of plasminogen activator inhibitor (PAI-1) and platelet GP1a. In addition, immunogenetic studies have been conducted to identify mechanisms that could be linked with the persistence/clearance of hantaviruses in reservoirs. Persistence was associated during experimental infections with an upregulation of anti-inflammatory responses. Using natural rodent population samples, polymorphisms and/or expression levels of several genes have been analyzed. These genes were selected based on the literature of rodent or human/hantavirus interactions (some Mhc class II genes, Tnf promoter, and genes encoding the proteins TLR4, TLR7, Mx2 and β3 integrin). The comparison of genetic differentiation estimated between bank vole populations sampled over Europe, at neutral and candidate genes, has allowed to evidence signatures of selection for Tnf, Mx2 and the Drb Mhc class II genes. Altogether, these results corroborated the hypothesis of an evolution of tolerance strategies in rodents. We finally discuss the importance of these results from the medical and epidemiological perspectives.
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来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3.2
作者：
Deter, Julie;Bryja, Josef;Charbonnel, Nathalie
通讯作者：
Charbonnel, Nathalie
DOI：
10.1073/pnas.0707453104
发表时间：
2007-09-25
影响因子：
11.1
作者：
Easterbrook, Judith D.;Zink, M. Christine;Klein, Sabra L.
通讯作者：
Klein, Sabra L.
影响因子：
5.4
作者：
Gavrilovskaya, IN;Brown, EJ;Mackow, ER
通讯作者：
Mackow, ER
影响因子：
3.7
作者：
Choi, Yun;Kwon, Young-Chan;Ahn, Byung-Yoon
通讯作者：
Ahn, Byung-Yoon