Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage. The effects of antiasthmatic treatment with budesonide or terbutaline.
Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage. The effects of antiasthmatic treatment with budesonide or terbutaline.
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通过支气管肺泡灌洗研究哮喘患者的炎症细胞和嗜酸性粒细胞活性。
DOI：
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
P. Venge
中科院分区：
文献类型：
--
作者：
E. Ädelroth;L. Rosenhall;Sten;M. Linden;P. Venge
我们研究了11例偶尔吸入支气管扩张剂（A组）和11例定期吸入皮质类固醇（B组）患者支气管肺泡灌洗（BAL）的细胞分布和释放嗜酸性阳离子蛋白（ECP）的成分。还招募了12名受试者的正常健康对照组。与A组相比，B组的输注量恢复百分比（p <0.05）和总细胞数恢复百分比（p <0.01）降低。与对照组相比，两组哮喘患者的嗜酸性粒细胞百分比均显著升高（p <0.05）。在A组中，肥大细胞（p <0.05）、血清ECP（p <0.05）和BAL-ECP（p <0.001）也显著增加。在任何组中，任何细胞变量和气道反应性水平（以PC 20组胺计）之间均无相关性。A组患者接受了两次调查-在随机分配的常规β 2受体激动剂（特布他林250微克，每天4次，每次2喷）或常规吸入皮质类固醇（布地奈德200微克，每天2次）治疗4周之前和之后。BAL分类细胞计数相似，不受任何治疗的显著影响。然而，BAL-ECP水平下降布地奈德治疗（p <0.05）。血清和BAL中ECP水平显著相关（p <0.05至0.001）。本研究进一步强调了嗜酸性粒细胞参与哮喘，但嗜酸性粒细胞数量的增加似乎不如其活性重要，此处测量为一种脱粒产物ECP的释放。为了抑制疾病的活动，重复的长期治疗是重要的，但根据我们目前的结果，不能明确选择哪种治疗。
We investigated the constituents of bronchoalveolar lavage (BAL) regarding cell profiles and released eosinophilic cationic protein (ECP) in 11 patients treated occasionally with inhaled bronchodilators (Group A) and 11 patients treated regularly with inhaled corticosteroids (Group B). A normal, healthy control group of 12 subjects was also recruited. Compared with Group A, Group B had a reduced recovery percentage of infused volume (p less than 0.05) and total cell number (p less than 0.01). Compared with the control group, there was a significant increase in the percentage of eosinophils (p less than 0.05) in both groups of asthmatics. In Group A there was also a significant increase in mast cells (p less than 0.05), serum-ECP (p less than 0.05), and BAL-ECP (p less than 0.001). No correlations between any of the cell variables and the level of airway responsiveness measured as PC20 histamine were found in any group. Group A patients were investigated twice--before and after 4 wk of randomly allocated treatment with either a regular beta-2-receptor agonist (terbutaline 250 micrograms, two puffs four times a day) or a regularly inhaled corticosteroid (budesonide 200 micrograms twice a day). The BAL differential cell counts were similar and not significantly affected by either treatment. However, BAL-ECP levels were decreased by budesonide treatment (p less than 0.05). ECP levels in serum and BAL were significantly correlated (p less than 0.05 to 0.001). The eosinophilic cell involvement in asthma is further emphasized by this study but the increase in numbers of eosinophils seems less important than their activity, here measured as release of one degranulation product, ECP. To suppress disease activity, repeated long-term treatment is important, but clear preference for either treatment cannot be given on the basis of our present results.
影响因子：
9.6
作者：
G. Gleich;D. Loegering;C. Adolphson
通讯作者：
G. Gleich;D. Loegering;C. Adolphson
DOI：
10.1164/ajrccm/137.1.62
发表时间：
1988
期刊：
The American review of respiratory disease
影响因子：
--
作者：
A. Wardlaw;S. Dunnette;G. Gleich;J. Collins;A. Kay
通讯作者：
A. Wardlaw;S. Dunnette;G. Gleich;J. Collins;A. Kay