Negative Bias During Early Attentional Engagement in Major Depressive Disorder as Examined Using a Two-Stage Model: High Sensitivity to Sad but Bluntness to Happy Cues.
Negative Bias During Early Attentional Engagement in Major Depressive Disorder as Examined Using a Two-Stage Model: High Sensitivity to Sad but Bluntness to Happy Cues.
复制标题
DOI：
10.3389/fnhum.2020.593010
复制
发表时间：
2020
影响因子：
2.9
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Ao X;Mo L;Wei Z;Yu W;Zhou F;Zhang D
负性注意偏向在抑郁症中已经得到了很好的证实。然而，与持续注意投入期间的负偏倚的趋同证据相比，关于这种与抑郁相关的负偏倚是否在初始注意分配期间存在的知识非常有限。本研究采用行为学和电生理两种方法研究情绪一致和情绪不一致对抑郁症患者初始注意投入的影响。点探测任务是在100毫秒的情绪线索（情绪和中性面孔对）暴露时间下进行的。行为实验结果表明，有效的面部表情提示比无效的面部表情提示反应更快。两阶段注意调节模型框架下的电生理指标提供了不同注意投入阶段的认知机制：(1)与健康对照组相比，患者在有效快乐提示后的P1波幅比无效快乐提示后的P1波幅减小，表明自动注意定向在早期阶段呈正向衰减；(2)有效悲伤提示后P3波幅增强，而无效悲伤提示后P3波幅减弱，表明抑郁在自上而下的自主注意控制后期存在情绪一致性负增强。抑郁症患者在早期注意分配中表现出负向偏倚，表现为对情绪一致性的偏好和对积极情绪线索/刺激的减少。
Negative attentional bias has been well established in depression. However, there is very limited knowledge about whether this depression-relevant negative bias exits during initial attentional allocation, as compared with the converging evidence for the negative bias during sustained attention engagement. This study used both behavioral and electrophysiological measures to examine the initial attention engagement in depressed patients influenced by mood-congruent and mood-incongruent emotions. The dot-probe task was performed with a 100-ms exposure time of the emotional cues (emotional and neutral face pairs). The behavioral results showed that the patients responded faster following valid compared with invalid sad facial cues. Electrophysiological indexes in the frame of the two-stage model of attentional modulation by emotions provided cognitive mechanisms in distinct attention engagement stages: (1) the patients exhibited reduced P1 amplitudes following validly than invalidly happy cues than did the healthy controls, indicating a positive attenuation at an early stage of automatic attention orientation; and (2) the patients exhibited enhanced whereas the controls showed reduced P3 amplitudes following validly than invalidly sad cues, suggesting a mood-congruent negative potentiation in depression at the later stage of top-down voluntary control of attention. Depressed patients show a negative bias in early attentional allocation, reflected by preferred engagement with mood-congruent and diminished engagement with positive emotional cues/stimuli.
登录
查看更多内容
影响因子：
4.4
作者：
Ferrari GR;Becker ES;Smit F;Rinck M;Spijker J
通讯作者：
Spijker J
影响因子：
6.9
作者：
Fritzsche, A.;Dahme, B.;Gotlib, I. H.;Joormann, J.;Magnussen, H.;Watz, H.;Nutzinger, D. O.;von Leupoldt, A.
通讯作者：
von Leupoldt, A.
影响因子：
2.9
作者：
De Raedt, Rudi;Koster, Ernst H. W.
通讯作者：
Koster, Ernst H. W.
影响因子：
2.6
作者：
Atchley, Ruth Ann;Ilardi, Stephen S.;Lepping, Rebecca J.
通讯作者：
Lepping, Rebecca J.
影响因子：
4.6
作者：
Gotlib, IH;Kasch, KL;Johnson, SL
通讯作者：
Johnson, SL