Racial Disparities in Liver Transplantation for Hepatocellular Carcinoma: Analysis of the National Inpatient Sample From 2007 to 2014.

Racial Disparities in Liver Transplantation for Hepatocellular Carcinoma: Analysis of the National Inpatient Sample From 2007 to 2014.
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肝细胞癌肝移植的种族差异:2007 年至 2014 年全国住院患者样本分析。

DOI:
10.1097/mcg.0000000000001675
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发表时间:
2023
影响因子:
2.9
通讯作者:
Pyrsopoulos,Nikolaos
Pyrsopoulos,Nikolaos
中科院分区:
医学3区
文献类型:
--
作者:
Bodek,DanielD;Everwine,MatthewM;Lunsford,KeriE;Okoronkwo,Nneoma;Patel,PavanA;Pyrsopoulos,Nikolaos

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背景:肝细胞癌(HCC)仍然是一种致命的疾病,患者治愈的最大希望是肝移植;然而,在历史上,不同种族之间获得医疗资源(如供体器官)是不平衡的。确保公平获得供体肝脏对于尽量减少HCC结果的差异至关重要。因此,我们试图更好地阐明移植率之间的差异,不同种族groups.Materials和方法:全国住院病人样本(NIS)被用来评估差异,在肝移植的患者,其主要或次要诊断记录为肝癌或肝癌。该研究纳入了2007年至2014年期间至少有1例肝移植记录的中心的住院病例。结果:在70,406例加权住院病例中,共进行了7244例移植。黑人与较低的移植率相关,当考虑到一些可能的混杂因素,包括社会经济和地理因素时,调整后的比值比为0.46(95%置信区间:0.42-0.51,P< 0.01)。结论:我们的研究观察到,与白人相比,黑人肝移植率降低HCC。此外,经济状况的改善和私人保险有一个显着更高的比值比移植。需要医院层面的研究来澄清在大型管理数据集中不明显的混杂因素,并帮助更好地调查导致黑人移植率不太理想的因素。干预措施可能包括更优化的筛查政策和程序,改善跨学科管理和早期转诊。
Background:Hepatocellular carcinoma (HCC) remains a deadly disease, with patients’ best hope for a cure being liver transplantation; however, access to health care resources, such as donor organs, between ethnic groups has historically been unbalanced. Ensuring equitable access to donor livers is crucial to minimize disparities in HCC outcomes. As a result, we sought to better elucidate the differences in transplantation rates among various ethnic groups.Materials and Methods:The National Inpatient Sample (NIS) was utilized to evaluate for disparities in liver transplantation in patients whose primary or secondary diagnosis was recorded as HCC or hepatoma. The study included admissions between 2007 and 2014 to centers with at least 1 documented liver transplant.Results:A total of 7244 transplants were performed over 70,406 weighted admissions. Black race was associated with lower transplantation rates, with an adjusted odds ratio of 0.46 (95% confidence interval: 0.42-0.51, P< 0.01) when accounting for a number of possible confounders including socioeconomic and geographic factors.Conclusions:Our study observed decreased rates of liver transplant in blacks compared with whites for HCC. Furthermore, improved economic status and private insurance had a significantly higher odds ratio for transplantation. Hospital-level studies are needed to clarify confounding factors not apparent in large administrative datasets and help better investigate factors that lead to less optimal transplant rates among blacks. Interventions may include more optimal screening policies and procedures, improved interdisciplinary management, and earlier referrals.
DOI: --
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