iLIR database: A web resource for LIR motif-containing proteins in eukaryotes.
iLIR database: A web resource for LIR motif-containing proteins in eukaryotes.
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ILIR数据库：真核生物中含LIR基序蛋白的Web资源。
DOI：
10.1080/15548627.2016.1207016
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发表时间：
2016-10-02
期刊：
影响因子：
13.3
通讯作者：
Nezis IP
中科院分区：
文献类型：
--
作者：
Jacomin AC;Samavedam S;Promponas V;Nezis IP
ATG8家族蛋白是核心自噬机制中研究最深入的蛋白。它们是吞噬体伸长和闭合成适当的自噬小体所必需的。此外，从自噬过程的开始到自噬小体与溶酶体融合之前，Atg8家族蛋白都与噬菌体相关。除了它们在自噬生物发生中的意义外，它们还通过与选择性自噬受体蛋白相互作用而对选择性自噬至关重要，而选择性自噬受体蛋白是特定靶向底物进行自噬降解所必需的。在过去的几年中，研究发现，Atg8相互作用的蛋白不仅包括受体，还包括核心自噬机制的组件、与囊泡及其运输相关的蛋白，以及通过自噬选择性降解的特定蛋白。Atg8相互作用蛋白含有一个短线性的Lc3-相互作用区/Lc3识别序列/Atg8-相互作用基序(LIR/LRS/AIM)基序，负责它们与Atg8家族蛋白的相互作用。这些蛋白质被称为含LIR的蛋白质(LIRCP)。到目前为止，已经开展了许多实验努力来确定新的LIRCP，导致在过去10年中对其中一些进行了表征。考虑到在各种生物中鉴定LIRCP的需要，我们开发了ILIR数据库(https://ilir.warwick.ac.uk))作为一个免费的网络资源，使用ILIR服务器列出了在8个模式生物的蛋白质组中在Silico中鉴定的所有假定的典型LIRCP，并结合基因本体论(GO)术语分析。此外，对文献的精心策划的文本挖掘分析使我们能够在哺乳动物中识别出以前没有与自噬相关的新的假定LICRP。
Atg8-family proteins are the best-studied proteins of the core autophagic machinery. They are essential for the elongation and closure of the phagophore into a proper autophagosome. Moreover, Atg8-family proteins are associated with the phagophore from the initiation of the autophagic process to, or just prior to, the fusion between autophagosomes with lysosomes. In addition to their implication in autophagosome biogenesis, they are crucial for selective autophagy through their ability to interact with selective autophagy receptor proteins necessary for the specific targeting of substrates for autophagic degradation. In the past few years it has been revealed that Atg8-interacting proteins include not only receptors but also components of the core autophagic machinery, proteins associated with vesicles and their transport, and specific proteins that are selectively degraded by autophagy. Atg8-interacting proteins contain a short linear LC3-interacting region/LC3 recognition sequence/Atg8-interacting motif (LIR/LRS/AIM) motif which is responsible for their interaction with Atg8-family proteins. These proteins are referred to as LIR-containing proteins (LIRCPs). So far, many experimental efforts have been carried out to identify new LIRCPs, leading to the characterization of some of them in the past 10 years. Given the need for the identification of LIRCPs in various organisms, we developed the iLIR database (https://ilir.warwick.ac.uk) as a freely available web resource, listing all the putative canonical LIRCPs identified in silico in the proteomes of 8 model organisms using the iLIR server, combined with a Gene Ontology (GO) term analysis. Additionally, a curated text-mining analysis of the literature permitted us to identify novel putative LICRPs in mammals that have not previously been associated with autophagy.
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影响因子：
11.2
作者：
Fan S;Meng Q;Saha T;Sarkar FH;Rosen EM
通讯作者：
Rosen EM
DOI：
10.4161/jkst.25666
发表时间：
2013-10-01
期刊：
JAK-STAT
影响因子：
--
作者：
Bourke LT;Knight RA;Latchman DS;Stephanou A;McCormick J
通讯作者：
McCormick J
影响因子：
11.8
作者：
Fu, Meng-meng;Nirschl, Jeffrey J.;Holzbaur, Erika L. F.
通讯作者：
Holzbaur, Erika L. F.
影响因子：
4
作者：
Birgisdottir, Asa Birna;Lamark, Trond;Johansen, Terje
通讯作者：
Johansen, Terje
影响因子：
5.3
作者：
de Narvajas, Amaia Artal-Martinez;Gomez, Timothy S.;Billadeau, Daniel D.
通讯作者：
Billadeau, Daniel D.