Muscarinic and 5-HT4 receptors participate in the regulation of the frequency of spontaneous contractions of the longitudinal muscle in rat distal colon.
Muscarinic and 5-HT4 receptors participate in the regulation of the frequency of spontaneous contractions of the longitudinal muscle in rat distal colon.
复制标题
毒蕈碱受体和5-HT4受体参与大鼠远端结肠纵向肌自发收缩频率的调节。
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
A. Kuwahara
中科院分区：
文献类型：
--
作者：
S. Ono;R. Mitsui;Shin;A. Kuwahara
肠的自发性收缩被认为在胃肠运动中起着重要作用，包括痉挛。在本研究中，我们研究了自发收缩频率的调节机制，在大鼠远端结肠纵肌条。阿托品显著降低自发收缩的频率，表明通过毒蕈碱受体的神经肌肉传递增加自发收缩的频率。SB-204070，5-HT 4受体拮抗剂也显著降低自发收缩的频率，表明5-HT 4受体的激活也增加自发收缩的频率。结论：毒蕈碱受体和5-HT_4受体参与了大鼠远端结肠纵行肌自发收缩频率的调节，自发收缩频率受肠神经元控制。
Spontaneous contractions of the intestine are thought to play an important role in the gastrointestinal motility, including peristalsis. In the present study, we investigated mechanisms for regulation of the frequency of spontaneous contractions, using longitudinal muscle strips in rat distal colon. Atropine significantly decreased the frequency of spontaneous contractions, indicating that neuromuscular transmission via muscarinic receptors increases the frequency of spontaneous contractions. SB-204070, 5-HT4 receptor antagonist also significantly decreased the frequency of spontaneous contractions, indicating that the activation of 5-HT4 receptors also increases the frequency of spontaneous contractions. In conclusion, it is suggested that muscarinic and 5-HT4 receptors participate in the regulation of the frequency of spontaneous contractions in the longitudinal muscle in rat distal colon, and that the frequency of spontaneous contraction is controlled by the enteric neurons.
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DOI：
10.1152/ajpgi.2001.281.1.g275
发表时间：
2001-07-01
影响因子：
4.5
作者：
Gonzalez, A;Sarna, SK
通讯作者：
Sarna, SK
影响因子：
29.4
作者：
Grider, JR;Foxx-Orenstein, AE;Jin, JG
通讯作者：
Jin, JG
DOI：
--
发表时间：
1999
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
J. Jin;A. Foxx-Orenstein;J. Grider
通讯作者：
J. Jin;A. Foxx-Orenstein;J. Grider
DOI：
10.1152/ajpgi.00114.2001
发表时间：
2002-09-01
影响因子：
4.5
作者：
Li, M;Johnson, CP;Sarna, SK
通讯作者：
Sarna, SK