Acute effects of metoprolol on muscle sympathetic activity in hypertensive humans.
Acute effects of metoprolol on muscle sympathetic activity in hypertensive humans.
复制标题
美托洛尔对高血压人群肌肉交感神经活动的急性影响。
作者：
G. Sundlöf;B. Wallin;E. Strömgren;C. Nerhed
在静脉注射心脏选择性β-肾上腺素受体拮抗剂美托洛尔期间，对八名先前未经治疗的原发性高血压受试者的腓神经肌肉分支进行了多单位交感神经活动的记录。同时监测动脉血压和中心静脉压。使用美托洛尔后，所有受试者的心率均下降，中心静脉压升高。一些受试者的血压升高，另一些受试者的血压降低，而收缩期脉搏波的上升率有规律地降低。通过计算平均电压神经图中的突发数量及其幅度来定量以动作电位的脉冲同步突发形式释放的交感神经活动。在所有受试者中，平均舒张期与美托洛尔服用后比服用前更多的交感神经冲动流出相关。用药后总交感神经活动（表示为爆发/分钟乘以平均爆发强度）也增加。交感神经活性增加的机制可能是直接的中枢神经效应或动脉压力感受器或心脏受体引起的反射效应。
Recordings of multiunit sympathetic activity were made from muscle branches of the peroneal nerve in eight previously untreated subjects with essential hypertension during intravenous administration of the cardioselective beta-adrenoceptor antagonist, metoprolol. Intraarterial blood pressure and central venous pressure were monitored simultaneously. After metoprolol, heart rate fell and central venous pressure increased in all subjects. Blood pressure increased in some subjects and decreased in others whereas the rate of rise of the systolic pulse wave regularly decreased. Sympathetic activity, discharged in pulse synchronous bursts of action potentials, was quantitated by counting the number of bursts and their amplitudes in the mean voltage neurogram. In all subjects, the average diastole was associated with outflow of more sympathetic impulses after metoprolol than before. Total sympathetic activity (expressed as bursts/min multiplied by mean burst strength) also increased after the drug. The mechanism behind the increase of sympathetic activity may be either a direct central nervous effect or a reflex effect elicited from arterial baroreceptors or cardiac receptors.
人类颈动脉压力感受器活性突然改变引起的交感神经瞬变。
DOI：
10.1152/ajpheart.1982.242.2.h185
发表时间：
1982
期刊：
The American journal of physiology
影响因子：
--
作者：
Wallin,BG;Eckberg,DL
通讯作者：
Eckberg,DL