Laminar and Cellular Distribution of Monoamine Receptors in Rat Medial Prefrontal Cortex.
Laminar and Cellular Distribution of Monoamine Receptors in Rat Medial Prefrontal Cortex.
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DOI：
10.3389/fnana.2017.00087
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发表时间：
2017
影响因子：
2.9
通讯作者：
Artigas F
中科院分区：
文献类型：
--
作者：
Santana N;Artigas F
前额叶皮层（PFC）与高级脑功能密切相关，其中许多功能在精神疾病中会发生改变。PFC通过下行通路对大多数皮层和皮层下区域进行自上而下的控制，并被来自脑干单胺细胞群的轴突密集支配，即中缝背核和中缝核（分别为DR和MnR）、腹侧被盖区和蓝斑（LC）。反过来，这些细胞群的活性受到来自第V层PFC锥体神经元的传入通路的严格控制。PFC和单胺细胞群之间的相互连接对研究严重精神疾病（如重度抑郁症和精神分裂症）的病理生理和治疗有重要意义，因为抗抑郁和抗精神病药物靶向在这些区域表达的单胺受体/转运体。在这里，我们回顾了以前的报道，检查单胺受体的锥体和gaba能神经元的PFC双原位杂交的存在。此外，我们还提供了关于单胺受体表达细胞在内侧PFC （mPFC）的扣带区（Cg）、边缘前区（PrL）和边缘下区（IL）的定量层分布（I层、ii层- iii层、V层和VI层）的新数据。检测的受体包括5-羟色胺5-HT1A、5-HT2A、5-HT2C和5-HT3，多巴胺D1和D2受体，α1A-、α1B-和α 1d肾上腺素受体。除了5-HT3受体在I - iii层GABA中间神经元中选择性表达外，其余单胺受体在mPFC中、深层的锥体和GABA能神经元中广泛表达（5-HT2C受体也在I层表达）。这种复杂的分布表明，单胺可能通过激活神经元分别在中间层（如5-HT1A、5-HT2A、α 1d -肾上腺素受体、多巴胺D1受体）和深层（如5-HT1A、5-HT2A、α 1a -肾上腺素受体、多巴胺D2受体）表达的受体来调节PFC与皮质/皮质下区域之间的通信。总的来说，这些数据提供了一个详细的框架，可以更好地理解单胺在pfc处理认知和情绪信号中的作用。同样，它们可能有助于表征与抗抑郁药和抗精神病药物治疗作用相关的脑回路，并改善其治疗作用，克服当前药物的局限性。
The prefrontal cortex (PFC) is deeply involved in higher brain functions, many of which are altered in psychiatric conditions. The PFC exerts a top-down control of most cortical and subcortical areas through descending pathways and is densely innervated by axons emerging from the brainstem monoamine cell groups, namely, the dorsal and median raphe nuclei (DR and MnR, respectively), the ventral tegmental area and the locus coeruleus (LC). In turn, the activity of these cell groups is tightly controlled by afferent pathways arising from layer V PFC pyramidal neurons. The reciprocal connectivity between PFC and monoamine cell groups is of interest to study the pathophysiology and treatment of severe psychiatric disorders, such as major depression and schizophrenia, inasmuch as antidepressant and antipsychotic drugs target monoamine receptors/transporters expressed in these areas. Here we review previous reports examining the presence of monoamine receptors in pyramidal and GABAergic neurons of the PFC using double in situ hybridization. Additionally, we present new data on the quantitative layer distribution (layers I, II–III, V, and VI) of monoamine receptor-expressing cells in the cingulate (Cg), prelimbic (PrL) and infralimbic (IL) subfields of the medial PFC (mPFC). The receptors examined include serotonin 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT3, dopamine D1 and D2 receptors, and α1A-, α1B-, and α1D-adrenoceptors. With the exception of 5-HT3 receptors, selectively expressed by layers I–III GABA interneurons, the rest of monoamine receptors are widely expressed by pyramidal and GABAergic neurons in intermediate and deep layers of mPFC (5-HT2C receptors are also expressed in layer I). This complex distribution suggests that monoamines may modulate the communications between PFC and cortical/subcortical areas through the activation of receptors expressed by neurons in intermediate (e.g., 5-HT1A, 5-HT2A, α1D-adrenoceptors, dopamine D1 receptors) and deep layers (e.g., 5-HT1A, 5-HT2A, α1A-adrenoceptors, dopamine D2 receptors), respectively. Overall, these data provide a detailed framework to better understand the role of monoamines in the processing of cognitive and emotional signals by the PFC. Likewise, they may be helpful to characterize brain circuits relevant for the therapeutic action of antidepressant and antipsychotic drugs and to improve their therapeutic action, overcoming the limitations of current drugs.
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影响因子：
34.7
作者：
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