Five Years Pathological Evaluation of Corneal Regrafts: A Study from Southern Iran.
Five Years Pathological Evaluation of Corneal Regrafts: A Study from Southern Iran.
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DOI：
10.1155/2020/2546923
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发表时间：
2020
影响因子：
1.9
通讯作者：
Ashraf MJ
中科院分区：
文献类型：
--
作者：
Eghtedari M;Kamalzadeh M;Yasemi M;Movahedan H;Ashraf MJ
角膜移植有时需要在移植失败后恢复透明度。该研究的目的是对角膜移植的5年流行病学和组织病理学进行评估。在这项横断面研究中，对设拉子市Khalili眼科中心5年内（2012-2016年）的所有角膜移植进行了评估。人口统计数据包括年龄、居住地区、原发疾病、移植物类型、再移植物原因、初次和后续移植物间隔（IPSG）、相关眼病或手术以及全身性疾病。同时，我们也回顾了角膜的显微镜检查结果。1190例角膜移植中，76例为再移植，占6.38%。最常见的移植是穿透性角膜移植术（PK）。真菌性角膜炎IPSG最短。移植失败的主要原因分别是内皮功能障碍、感染、免疫排斥、技术问题和原发疾病复发。移植失败最常见的组织病理学发现是严重的内皮细胞丢失（89.8%）。此外，超过一半和三分之一的病例分别有内皮膜改变和间质长进。内皮细胞丢失是我们研究失败的主要原因。此外，感染病例，特别是真菌性角膜炎的复发率也很高。相当多的组织病理学改变，如角膜前膜加倍和角膜后纤维长入，需要进一步的研究。也许，改进角膜移植技术，评估供体组织和受体床，以及是否需要更长时间的医疗治疗，是未来研究的基础，以提高移植物的存活率。
Corneal regrafts sometimes needed to restore the transparency after graft failure. The aim of the study is five years epidemiologic and histopathological evaluation of corneal regrafts. In this cross-sectional study, all corneal regrafts during 5 years (2012–2016) were assessed in the Khalili Ophthalmology Center at Shiraz city. Demographic data including age, area of residence, primary disease, type of graft, cause of regraft, interval between primary and subsequent grafts (IPSG), associated eye diseases or surgeries, and systemic diseases were recorded. Also, microscopic findings of corneas were reviewed. Among a total of 1190 corneal grafts, 76 of them (6.38%) were regrafts. The most common type of grafting was penetrating keratoplasty (PK). The shortest IPSG was observed in fungal keratitis. Main causes of graft failure were endothelial dysfunction, infection, immunologic rejection, technical problems, and recurrence of primary disease, respectively. The most common histopathological finding in failed grafts was severe endothelial cell loss (89.8%). Also, more than half and one-third of cases had Descemet membrane changes and stromal ingrowth, respectively. Endothelial cell loss was the major cause of failure in our study. Also, recurrence rate in infective cases, especially fungal keratitis, was very high. Considerable presence of histopathological changes such as doubling of Descemet membrane and retrocorneal fibrous ingrowth need further investigations. Perhaps, modification in techniques of corneal grafting and assessment of donor tissue and recipient bed along with any need for longer medical treatment are the basis for future studies in order to increase graft survival.
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影响因子：
4.2
作者：
Jakobiec, Frederick A.;Bhat, Pooja
通讯作者：
Bhat, Pooja
DOI：
10.1007/bf00410138
发表时间：
1979-01-01
期刊：
ALBRECHT VON GRAEFES ARCHIV FUR KLINISCHE UND EXPERIMENTELLE OPHTHALMOLOGIE
影响因子：
--
作者：
LAHAV, M;CADET, JC
通讯作者：
CADET, JC
影响因子：
2.8
作者：
Lee, Janet A.;Djalilian, Ali R.;Edward, Deepak P.
通讯作者：
Edward, Deepak P.
影响因子：
2.8
作者：
Li, Jennifer Y.;Wilhelmus, Kirk R.
通讯作者：
Wilhelmus, Kirk R.
影响因子：
2.4
作者：
Sung, Mi Sun;Yoon, Kyung Chul
通讯作者：
Yoon, Kyung Chul