Receptive field properties and laminar organization of lateral geniculate nucleus in the gray squirrel (Sciurus carolinensis).

Receptive field properties and laminar organization of lateral geniculate nucleus in the gray squirrel (Sciurus carolinensis).
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灰松鼠(Sciurus carolinensis)外侧膝状核的感受野特性和层状组织。

DOI:
10.1152/jn.00474.2003
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发表时间:
2003
期刊:
Journal of neurophysiology.
影响因子:
--
通讯作者:
Nelson,SachaB
Nelson,SachaB
中科院分区:
--
文献类型:
--
作者:
VanHooser,StephenD;Heimel,JAlexanderF;Nelson,SachaB

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对外侧膝状体核(LGN)的生理研究揭示了三类中继神经元,在食肉动物中称为X、Y和W细胞,在灵长类动物中称为小细胞(P)、大细胞(M)和小细胞(K)。这些细胞类别之间的同源性关系,以及这些细胞的感受野(RF)特性与其他哺乳动物的LGN细胞相比,知之甚少。为了解决这些问题,我们的特点是射频特性和层状组织在LGN的高度视觉昼夜啮齿动物,灰松鼠,异氟烷麻醉下。我们确定了三类LGN细胞。在第1层和第2层中发现的一类显示出持续、可靠的发射,中心-环绕组织,并且在空间总和中几乎完全是线性的。另一类,发现在第3层,表现出短反应潜伏期,瞬态和可靠的发射,中心环绕组织,并可以显示线性(76%)或非线性(24%)的空间总和。第三,异构类发现整个LGN,但主要是在第3层表现出高度可变的反应,各种反应lavelets,可以显示中心环绕或非中心环绕感受野组织和线性(77%)或非线性(23%)的空间总和。所有细胞类别的RF大小表现出对偏心率的依赖性很小,并且所有这些类别都表现出低对比度增益。当与其他哺乳动物的LGN细胞相比时,我们的数据与以下观点一致:所有哺乳动物都含有三类基本的LGN神经元,一类显示可靠的,持续的反应和中心-周围组织(X或P);另一类显示短暂但可靠的反应,短潜伏期和中心-周围组织(Y或M);第三类细胞(W或K),高度可变和异质。其他属性,如依赖于偏心率,线性的空间总和,和对比度增益的感受野大小出现不同的物种。
Physiological studies of the lateral geniculate nucleus (LGN) have revealed three classes of relay neurons, called X, Y, and W cells in carnivores and parvocellular (P), magnocellular (M), and koniocellular (K) in primates. The homological relationships among these cell classes and how receptive field (RF) properties of these cells compare with LGN cells in other mammals are poorly understood. To address these questions, we have characterized RF properties and laminar organization in LGN of a highly visual diurnal rodent, the gray squirrel, under isoflurane anesthesia. We identified three classes of LGN cells. One class found in layers 1 and 2 showed sustained, reliable firing, center-surround organization, and was almost exclusively linear in spatial summation. Another class, found in layer 3, showed short response latencies, transient and reliable firing, center-surround organization, and could show either linear (76%) or nonlinear (24%) spatial summation. A third, heterogeneous class found throughout the LGN but primarily in layer 3 showed highly variable responses, a variety of response latencies and could show either center-surround or noncenter-surround receptive field organization and either linear (77%) or nonlinear (23%) spatial summation. RF sizes of all cell classes showed little dependency on eccentricity, and all of these classes showed low contrast gains. When compared with LGN cells in other mammals, our data are consistent with the idea that all mammals contain three basic classes of LGN neurons, one showing reliable, sustained responses, and center-surround organization (X or P); another showing transient but reliable responses, short latencies, and center-surround organization (Y or M); and a third, highly variable and heterogeneous class of cells (W or K). Other properties such as dependency of receptive field size on eccentricity, linearity of spatial summation, and contrast gain appear to vary from species to species.
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DOI: --
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