Prevention of ethanol-induced changes in reactive oxygen parameters by α-tocopherol
Prevention of ethanol-induced changes in reactive oxygen parameters by α-tocopherol
复制标题
α-生育酚预防乙醇引起的活性氧参数变化
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
J. D. Adams
中科院分区：
文献类型：
--
作者：
S. Bondy;Shirley Guo;J. D. Adams
Rats were given a 200 mg/kg body weight daily dose of alpha-tocopherol by i.p. injection for 15 days. This resulted in elevated levels of glutathione in both liver and brain, and in a reduced hepatic rate of generation of reactive oxygen species. The depression of hepatic and cerebral glutathione levels in ethanol-consuming rats was prevented by simultaneous treatment with alpha-tocopherol. Other putative indices of hepatic pro-oxidant events, namely levels of mixed function oxidase and proteolytic activity, were elevated by alpha-tocopherol both in the presence and absence of ethanol. In addition, levels of enzymes especially susceptible to oxidative degradation, glutamine synthetase and creatine kinase, were depressed in the liver following treatment with ethanol or alpha-tocopherol. Parameters rapidly responsive to oxidative changes revealed the antioxidant property of alpha-tocopherol, while protein-based indices reflecting more extended events suggested a pro-oxidant effect of this vitamin. Results suggest that high levels of alpha-tocopherol can simultaneously lead to a more reduced intracellular environment and yet to localized evidence of enhanced oxidative events.
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影响因子：
3.9
作者：
DAVIES, KJA
通讯作者：
DAVIES, KJA
影响因子：
5.8
作者：
BONDY, SC;NADERI, S
通讯作者：
NADERI, S
影响因子：
4.4
作者：
D. Bass;J. W. Parce;L. Dechatelet;P. Szejda;M. Seeds;M. Thomas
通讯作者：
D. Bass;J. W. Parce;L. Dechatelet;P. Szejda;M. Seeds;M. Thomas
利用一氯代二胺通过流式细胞术定量分析细胞谷胱甘肽：在体外和体内辐射和耐药性方面的一些应用。
影响因子：
11.2
作者：
Rice,GC;Bump,EA;Shrieve,DC;Lee,W;Kovacs,M
通讯作者：
Kovacs,M
DOI：
10.1016/0926-6917(94)90011-6
发表时间：
1994-08-03
期刊：
EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION
影响因子：
--
作者：
BONDY, SC;GUO, SX
通讯作者：
GUO, SX