Doxorubicin loaded ferritin nanoparticles for ferroptosis enhanced targeted killing of cancer cells.
Doxorubicin loaded ferritin nanoparticles for ferroptosis enhanced targeted killing of cancer cells.
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负载阿霉素的铁蛋白纳米粒子用于铁死亡增强对癌细胞的靶向杀伤
作者：
近年来，铁下垂作为一种新的细胞死亡形式被广泛研究。开发纳米药物诱导癌细胞铁下垂可能是一种很有前途的癌症治疗方法。在这里，我们开发了一种由抗肿瘤药物阿霉素和外源性铁蛋白组成的纳米颗粒。载药过程对铁蛋白的大小变化不明显。该纳米颗粒可诱导转铁蛋白受体过表达的肿瘤细胞HT29的ROS积累和细胞凋亡。使用铁下垂抑制剂也证实了铁下垂过程。该纳米颗粒的细胞毒性与游离DOX相似。本研究为靶向和杀伤转铁蛋白受体过表达的肿瘤细胞提供了新的策略。
In recent years, ferroptosis has been investigated widely as a new form of cell death. Development of nanodrugs for ferroptosis induction in cancer cells may be a promising approach for cancer treatment. Here, we developed a type of nanoparticle consisting of the antitumor drug doxorubicin and exogenous ferritin. The drug loading process did not change the size of ferritin obviously. And this nanoparticle could induce the accumulation of ROS and cell ferroptosis for transferrin receptor overexpressed tumor cell, HT29. The ferroptosis process was also confirmed using inhibitors for ferroptosis. The cytotoxicity of this nanoparticle is similar to that of free DOX. This study provides a new strategy for targeting and killing transferrin receptor overexpressed tumor cells.
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影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
2.6
作者：
Thorn CF;Oshiro C;Marsh S;Hernandez-Boussard T;McLeod H;Klein TE;Altman RB
通讯作者：
Altman RB
影响因子：
64.8
作者：
Sengupta, S;Eavarone, D;Sasisekharan, R
通讯作者：
Sasisekharan, R
二氧化钛纳米颗粒的修饰可增强活性氧的光催化产生，而无需在体外增加毒性潜力。
影响因子：
3.9
作者：
Ortelli, Simona;Costa, Anna L.;Matteucci, Pietro;Miller, Mark R.;Blosi, Magda;Gardini, Davide;Tofail, Syed A. M.;Lang Tran;Tonelli, Domenica;Poland, Craig A.
通讯作者：
Poland, Craig A.
影响因子：
29
作者：
Seiler, Alexander;Schneider, Manuela;Conrad, Marcus
通讯作者：
Conrad, Marcus