Silica modification of titania nanoparticles enhances photocatalytic production of reactive oxygen species without increasing toxicity potential in vitro.
Silica modification of titania nanoparticles enhances photocatalytic production of reactive oxygen species without increasing toxicity potential in vitro.
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二氧化钛纳米颗粒的修饰可增强活性氧的光催化产生，而无需在体外增加毒性潜力。
DOI：
10.1039/c8ra07374k
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发表时间：
2018-11-28
期刊：
影响因子：
3.9
通讯作者：
Poland, Craig A.
中科院分区：
文献类型：
--
作者：
Ortelli, Simona;Costa, Anna L.;Matteucci, Pietro;Miller, Mark R.;Blosi, Magda;Gardini, Davide;Tofail, Syed A. M.;Lang Tran;Tonelli, Domenica;Poland, Craig A.
二氧化硅和柠檬酸盐对二氧化钛纳米粒子进行了表面改性，通过控制表面氧化还原反应性，实现了一种“设计安全”的方法，以控制二氧化钛纳米粒子的潜在毒性。DLS和ζ电位分析证实了表面修饰，电子显微镜和表面积测量显示了颗粒的纳米级尺寸。采用电子顺磁共振（EPR）测定外源活性氧（ROS）的生成。与相应的分散纳米二氧化钛相比，所有制备的喷雾干燥纳米二氧化钛的ROS水平都有所降低，这表明喷雾干燥工艺是控制纳米二氧化钛ROS反应性的一种合适的设计策略。用二氧化硅和柠檬酸盐修饰纳米二氧化钛导致外源测量中ROS生成水平增加，包括光激发60分钟。二氯二氢荧光素（DCFH）测定了巨噬细胞和肺泡上皮细胞中由原始和修饰的纳米二氧化钛产生的氧化应激的剂量依赖性，发现由活性氧产生的毒性没有显著变化。我们的研究结果表明，纳米二氧化钛的光催化活性与其氧化应激介导的潜在毒性之间没有直接的相关性，并且有可能在不改变细胞氧化还原平衡的情况下改善前者，例如添加二氧化硅作为改性剂。二氧化硅和柠檬酸盐对二氧化钛纳米粒子进行了表面改性，通过控制表面氧化还原反应性，实现了一种“设计安全”的方法，以控制二氧化钛纳米粒子的潜在毒性。
Titania (TiO2) nanoparticles were surface modified using silica and citrate to implement a ‘safe-by-design’ approach for managing potential toxicity of titania nanoparticles by controlling surface redox reactivity. DLS and zeta-potential analyses confirmed the surface modification, and electron microscopy and surface area measurements demonstrated nanoscale dimensions of the particles. Electron paramagnetic resonance (EPR) was used to determine the exogenous generation of reactive oxygen species (ROS). All the produced spray dried nanotitania lowered levels of ROS when compared to the corresponding dispersed nanotitania, suggesting that the spray drying process is an appropriate design strategy for the control of nano TiO2 ROS reactivity. The modification of nanotitania with silica and with citrate resulted in increased levels of ROS generation in exogenous measurements, including photoexcitation for 60 minutes. The dichlorodihydrofluorescein (DCFH) assay of dose-dependent production of oxidative stress, generated by pristine and modified nanotitania in macrophages and alveolar epithelial cells, found no significant change in toxicity originating from the generation of reactive oxygen species. Our findings show that there is no direct correlation between the photocatalytic activity of nanotitania and its oxidative stress-mediated potential toxicity, and it is possible to improve the former, for example adding silica as a modifying agent, without altering the cell redox equilibrium. Titania (TiO2) nanoparticles were surface modified using silica and citrate to implement a ‘safe-by-design’ approach for managing potential toxicity of titania nanoparticles by controlling surface redox reactivity.
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影响因子：
11.4
作者：
George, Saji;Gardner, Hannah;Chan, Woon Khiong
通讯作者：
Chan, Woon Khiong
影响因子：
10.4
作者：
Miller MR;Borthwick SJ;Shaw CA;McLean SG;McClure D;Mills NL;Duffin R;Donaldson K;Megson IL;Hadoke PW;Newby DE
通讯作者：
Newby DE
影响因子：
4.3
作者：
Mangini, Vincenzo;Dell'Aglio, Marcella;Arnesano, Fabio
通讯作者：
Arnesano, Fabio
影响因子：
5
作者：
Ekstrand-Hammarstrom, Barbro;Akfur, Christine M.;Bucht, Anders
通讯作者：
Bucht, Anders
影响因子：
3.5
作者：
Janer, G.;Mas del Molino, E.;Vazquez-Campos, S.
通讯作者：
Vazquez-Campos, S.