Stillbirth and fetal capillary infection by SARS-CoV-2.
Stillbirth and fetal capillary infection by SARS-CoV-2.
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DOI：
10.1016/j.ajogmf.2021.100523
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发表时间：
2022-01
影响因子：
6.3
通讯作者：
Brunelli R
中科院分区：
文献类型：
--
作者：
di Gioia C;Zullo F;Bruno Vecchio RC;Pajno C;Perrone G;Galoppi P;Pecorini F;Di Mascio D;Carletti R;Prezioso C;Pietropaolo V;Masuelli L;Bei R;Ciallella C;Della Rocca C;Giancotti A;Brunelli R
We presented the case of stillbirth in a paucisymptomatic mother affected by SARS-CoV-2. At gross examination, the placenta showed a diffuse marble appearance and a focal hemorrhagic area. Multiple areas of hemorrhagic or ischemic necrosis with central and peripheral villous infarctions and thrombosis of several maternal and fetal vessels with luminal fibrin and platelet deposition were observed. All lesions seemed to be synchronous. Virus particles were identified within the cytoplasm of endothelial cells using electron microscopy, whereas SARS-CoV-2 RNA was detected in the placental tissue using real-time reverse transcription-polymerase chain reaction. Here, fetal vascular malperfusion was associated with infection; in fact, electron microscopy images showed that marked SARS-CoV-2 endotheliotropism involved the intravillous fetal capillaries. Furthermore, we confirmed that syncytiotrophoblast is the major target cell type for SARS-CoV-2 infection of the placenta. In conclusion, the possible consequences of the action of the placentotropic SARS-CoV-2 included the occurrence of vertical transmission, as reported in the literature, and/or stillbirth: the latter possibility may be triggered by a hampered maternal and/or fetal perfusion of the placenta. The diffuse thrombosis and subsequent ischemia of fetal capillaries induced by COVID-19 cannot be predicted by standard clinical surveillance.
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影响因子：
9.8
作者：
Gurol-Urganci I;Jardine JE;Carroll F;Draycott T;Dunn G;Fremeaux A;Harris T;Hawdon J;Morris E;Muller P;Waite L;Webster K;van der Meulen J;Khalil A
通讯作者：
Khalil A
影响因子：
3.6
作者：
Mavilia MG;Wu GY
通讯作者：
Wu GY
DOI：
10.3390/v13050723
发表时间：
2021-04-21
期刊：
Viruses
影响因子：
--
作者：
Resta L;Vimercati A;Cazzato G;Mazzia G;Cicinelli E;Colagrande A;Fanelli M;Scarcella SV;Ceci O;Rossi R
通讯作者：
Rossi R
DOI：
10.1146/annurev-virology-031413-085524
发表时间：
2014-01-01
期刊：
ANNUAL REVIEW OF VIROLOGY, VOL 1
影响因子：
--
作者：
Delorme-Axford, Elizabeth;Sadovsky, Yoel;Coyne, Carolyn B.
通讯作者：
Coyne, Carolyn B.
影响因子：
11.1
作者：
Facchetti, Fabio;Bugatti, Mattia;Lavazza, Antonio
通讯作者：
Lavazza, Antonio