Introductory lecture: basic quantities in model biomembranes.
Introductory lecture: basic quantities in model biomembranes.
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DOI：
10.1039/c2fd20121f
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发表时间：
2013
影响因子：
3.4
通讯作者：
Nagle JF
中科院分区：
文献类型：
--
作者：
Nagle JF
在这场法拉第讨论中涉及到的膜生物物理学的许多方面之一是关于在超分子水平上描述能量的材料模数。这场介绍性讲座首先批判性地回顾了所报道的弯曲模数Kc数值的差异，弯曲模数Kc是膜的重要生物柔性的核心属性。推测可能有一个原因，即形状分析方法往往比微观机械操作方法或最近的X射线方法给出更大的Kc值，这两种方法彼此吻合得很好。膜生物物理学的另一个主题是使用模拟来提供结构和过程的精细细节。这堂课批判性地回顾了原子级模拟在简单的单组分脂双层定量结构中的应用，并引入诊断学来评估模拟。这场法拉第讨论的另一个主题是具有许多不同脂质的生物膜的横向异质性。粗粒度模拟和分析理论有望协同加强实验研究，当它们的相互作用参数被调整到与实验数据一致时，例如三元相图中实验联络线的斜率。最后，请注意将相关生物分子添加到双分子层中的贡献，以及研究具有不同脂类的不同非双层结构和令人兴奋的形状变化的贡献。
One of the many aspects of membrane biophysics dealt with in this Faraday Discussion regards the material moduli that describe energies at a supramolecular level. This introductory lecture first critically reviews differences in reported numerical values of the bending modulus KC, which is a central property for the biologically important flexibility of membranes. It is speculated that there may be a reason that the shape analysis method tends to give larger values of KC than the micromechanical manipulation method or the more recent X-ray method that agree very well with each other. Another theme of membrane biophysics is the use of simulations to provide exquisite detail of structures and processes. This lecture critically reviews the application of atomic level simulations to the quantitative structure of simple single component lipid bilayers and diagnostics are introduced to evaluate simulations. Another theme of this Faraday Discussion was lateral heterogeneity in biomembranes with many different lipids. Coarse grained simulations and analytical theories promise to synergistically enhance experimental studies when their interaction parameters are tuned to agree with experimental data, such as the slopes of experimental tie lines in ternary phase diagrams. Finally, attention is called to contributions that add relevant biological molecules to bilayers and to contributions that study the exciting shape changes and different non-bilayer structures with different lipids.
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影响因子：
3.3
作者：
Klauda, Jeffery B.;Venable, Richard M.;Freites, J. Alfredo;O'Connor, Joseph W.;Tobias, Douglas J.;Mondragon-Ramirez, Carlos;Vorobyov, Igor;MacKerell, Alexander D., Jr.;Pastor, Richard W.
通讯作者：
Pastor, Richard W.
影响因子：
3.4
作者：
Hague, Charlotte V.;Postle, Anthony D.;Dymond, Marcus K.
通讯作者：
Dymond, Marcus K.
影响因子：
3.4
作者：
Honigmann, Alf;Mueller, Veronika;Eggeling, Christian
通讯作者：
Eggeling, Christian
影响因子：
3.4
作者：
Chung, Minsub;Koo, Bon Jun;Boxer, Steven G.
通讯作者：
Boxer, Steven G.
影响因子：
3.4
作者：
Benz, RW;Castro-Román, F;White, SH
通讯作者：
White, SH