The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers
The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers
复制标题
烷基侧基对聚乙二醇-嵌段多肽共聚物二级结构和结晶的影响
DOI：
10.1016/j.polymer.2013.02.038
复制
发表时间：
2013-04
期刊：
影响因子：
4.6
通讯作者：
Chen Xuesi
中科院分区：
文献类型：
--
作者：
Ren Kaixuan;Cheng Yilong;He Chaoliang;Xiao Chunsheng;Li Gao;Chen Xuesi
研究了一系列聚乙二醇-聚谷氨酸-γ-烷基酯嵌段共聚物（PEG-b-PALG）的固态和熔融纳米级结构，正丁基、正己基、正辛基和正十二烷基，已经在本工作中进行了研究。烷基侧基对多肽链段的二级构象、PEG链段的结晶和共聚物的形态有着重要的影响。随着烷基侧基长度的增加或温度的升高，主要的二级结构逐渐由α-螺旋构象转变为β-折叠构象。差示扫描量热法、广角X-射线衍射分析和偏光显微镜观察表明，聚乙二醇链段的结晶和形态明显受到多肽嵌段的限制。因此，烷基侧基不仅对多肽链段的构象有显著影响，而且对PEG链段的结晶也有影响。这些合成生物材料的二级结构，结晶和球晶形态，这是显着的烷基侧基的影响，可能发挥重要作用，在其物理化学性质，如自组装，以及在一些生物医学应用。
The solid state and melt nanoscale structures of a series of poly(ethylene glycol)-block-poly(γ-alkyl-l-glutamate)s (PEG-b-PALG) copolymers bearing different alkyl side groups, i.e., n-butyl, n-hexyl, n-octyl, and n-dodecyl, have been investigated in the present work. An interesting effect of alkyl side groups on the secondary conformation of polypeptide block, crystallization of PEG segments and morphology of the copolymers was observed. With increasing the length of alkyl side groups or raising the temperature, the predominant secondary structure gradually changed from α-helix to β-sheet conformation. Differential scanning calorimetry, wide-angle X-ray diffraction analysis and polarized optical microscopy indicated that the crystallization and morphology of PEG segments were markedly restricted by the polypeptide block. Therefore, the alkyl side groups not only exhibited significant influence on the conformation of polypeptide block, but also affected the crystallization of PEG segments. The secondary structure, crystallization and spherulite morphology of these synthetic biomaterials, which were significantly influenced by alkyl side groups, may play an important role in their physicochemical properties, such as self-assembly, as well as in some biomedical applications.
登录
查看更多内容
影响因子：
5.5
作者：
A. Gitsas;G. Floudas;M. Dietz;M. Mondeshki;H. Spiess;G. Wegner
通讯作者：
A. Gitsas;G. Floudas;M. Dietz;M. Mondeshki;H. Spiess;G. Wegner
影响因子：
4.6
作者：
Minh Khanh Nguyen;Lee, Doo Sung
通讯作者：
Lee, Doo Sung
影响因子：
4.6
作者：
I. Polec;T. Fujiwara;T. Kanaya;C. Deng
通讯作者：
I. Polec;T. Fujiwara;T. Kanaya;C. Deng
DOI：
10.1021/bk-1992-0493.ch023
发表时间：
1992-06
期刊：
--
影响因子：
--
作者：
W. Daly;I. Negulescu;P. Russo;D. Poché
通讯作者：
W. Daly;I. Negulescu;P. Russo;D. Poché
影响因子：
6.2
作者：
K. Kuwabara;Z. Gan;Takashi Nakamura;H. Abe;Y. Doi
通讯作者：
K. Kuwabara;Z. Gan;Takashi Nakamura;H. Abe;Y. Doi