How Can Synergism of Traditional Medicines Benefit from Network Pharmacology?
How Can Synergism of Traditional Medicines Benefit from Network Pharmacology?
复制标题
传统药物的协同作用如何从网络药理学中受益？
DOI：
10.3390/molecules22071135
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发表时间：
2017-07-07
期刊：
影响因子：
--
通讯作者：
Piao G
中科院分区：
文献类型：
--
作者：
Yuan H;Ma Q;Cui H;Liu G;Zhao X;Li W;Piao G
许多中药方剂的疗效已经在临床实践中得到验证，具有很大的治疗价值，是一种很好的药物发现资源。中药单一化合物的研究取得了巨大的成功，如青蒿素；然而，很明显，TM处方（通常包含各种草药或其他成分）在治疗或减少毒性方面具有协同作用。网络药理学以生物网络为目标，分析这些网络中药物、靶点和疾病之间的联系。对网络药理学进行全面、系统的研究符合整体性的观点，这是许多传统医学的主要特点。通过网络药理学的研究表明，许多TM在不同水平上作用于多个靶点和途径，表现出协同效应。该方法有效地弥合了现代医学与中药之间的差距，极大地促进了中药协同作用的研究。中药具有不同类型的协同作用，如草药间协同、有效部位协同、纯化合物协同等；然而，由于种种原因，目前的新药开发应侧重于纯化合物之间的协同作用。
Many prescriptions of traditional medicines (TMs), whose efficacy has been tested in clinical practice, have great therapeutic value and represent an excellent resource for drug discovery. Research into single compounds of TMs, such as artemisinin from Artemisia annua L., has achieved great success; however, it has become evident that a TM prescription (which frequently contains various herbs or other components) has a synergistic effect in effecting a cure or reducing toxicity. Network pharmacology targets biological networks and analyzes the links among drugs, targets, and diseases in those networks. Comprehensive, systematic research into network pharmacology is consistent with the perspective of holisticity, which is a main characteristic of many TMs. By means of network pharmacology, research has demonstrated that many a TM show a synergistic effect by acting at different levels on multiple targets and pathways. This approach effectively bridges the gap between modern medicine and TM, and it greatly facilitates studies into the synergistic actions of TMs. There are different kinds of synergistic effects with TMs, such as synergy among herbs, effective parts, and pure compounds; however, for various reasons, new drug discovery should at present focus on synergy among pure compounds.
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