Neural sensitivity to phonological characteristics is stable across the lifespan.
Neural sensitivity to phonological characteristics is stable across the lifespan.
复制标题
DOI：
10.1016/j.neuroimage.2020.117511
复制
发表时间：
2021-01-15
期刊：
影响因子：
5.7
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Diaz MT;Karimi H;Troutman SBW;Gertel VH;Cosgrove AL;Zhang H
衰老通常与语言能力的下降有关。例如，与年轻人相比，老年人经历更多的舌尖（TOT）状态，命名物体的速度和准确性下降，并且言语中有更多的停顿和填充物，所有这些都表明与年龄相关的检索难度增加。虽然先前的研究表明检索困难可能是基于语音的，但目前尚不清楚语音信息本身的组织是否存在与年龄相关的差异，或者访问该信息是否可能会出现与年龄相关的困难。在这里，我们使用功能磁共振成像来研究语音邻域密度 (PND) 对整个生命周期图片命名影响的神经和行为基础（N = 91，年龄 20-75）。与之前的研究一致，行为结果显示较高的 PND 会导致更快的图片命名时间和更高的整体准确性，而老年人的反应不太准确。与行为分析一致，功能磁共振成像分析表明，PND 增加与听觉和运动语言区域（包括双侧颞上回和双侧中央前回）激活减少相关。有趣的是，尽管图片命名的功能激活与年龄相关，但对 PND 的神经敏感性却没有与年龄相关的调节。总体而言，这些结果表明，拥有大量语音邻居有助于语言产生，尽管衰老与语言产生难度的增加有关，但语言产生过程中对语音特征的敏感性在整个生命周期中是稳定的。
Aging is often associated with declines in language production. For example, compared to younger adults, older adults experience more tip-of-the-tongue (TOT) states, show decreased speed and accuracy in naming objects, and have more pauses and fillers in speech, all of which indicate age-related increases in retrieval difficulty. While prior work has suggested that retrieval difficulty may be phonologically based, it is unclear whether there are age-related differences in the organization of phonological information per se or whether age-related difficulties may arise from accessing that information. Here we used fMRI to investigate the neural and behavioral basis of phonological neighborhood denisty (PND) effects on picture naming across the lifespan (N=91, ages 20-75). Consistent with prior work, behavioral results revealed that higher PND led to faster picture naming times and higher accuracies overall, and that older adults were less accurate in their responses. Consistent with the behavioral analyses, fMRI analyses showed that increasing PND was associated with decreased activation in auditory and motor language regions, including bilateral superior temporal gyri and bilateral precentral gyri. Interestingly, although there were age-related increases in functional activation to picture naming, there were no age-related modulations of neural sensitivity to PND. Overall, these results suggest that having a large cohort of phonological neighbors facilitates language production, and although aging is associated with increases in language production difficulty, sensitivity to phonological features during language production is stable across the lifespan.
登录
查看更多内容
影响因子：
8.2
作者：
Braver, TS;Barch, DA
通讯作者：
Barch, DA
影响因子：
5.7
作者：
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
3.7
作者：
Brodeur MB;Guérard K;Bouras M
通讯作者：
Bouras M
影响因子：
5.7
作者：
Abel, Stefanie;Dressel, Katharina;Huber, Walter
通讯作者：
Huber, Walter
影响因子：
2.9
作者：
Diaz, Michele T.;Johnson, Micah A.;Madden, David J.
通讯作者：
Madden, David J.