The impact of gene expression profile testing on confidence in chemotherapy decisions and prognostic expectations.
The impact of gene expression profile testing on confidence in chemotherapy decisions and prognostic expectations.
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基因表达谱测试对化学疗法决策和预后期望的信心的影响。
DOI：
10.1007/s10549-018-4988-3
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发表时间：
2019-01
影响因子：
3.8
通讯作者：
Ramsey SD
中科院分区：
文献类型：
--
作者：
Panattoni L;Lieu TA;Jayasekera J;O'Neill S;Mandelblatt JS;Etzioni R;Phelps CE;Ramsey SD
Little is known about whether gene expression profile (GEP) testing and specific recurrence scores (e.g. medium risk) improve women’s confidence in their chemotherapy decision or perceived recurrence risk. We evaluate the relationship between these outcomes and GEP testing. We surveyed women eligible for GEP testing (Stage I or II, Gr1–2, ER+, HER2-) identified through the SEER registry of Washington or Kaiser Permanente Northern California from 2012–2016, approximately 0–4 years from diagnosis (N = 904, RR = 45.4%). Confidence about chemotherapy was measured as confident (Very, completely) vs. not confident (Somewhat, A little, Not At All); perceived risk recurrence was recorded numerically (0–100%). Women reported their GEP test receipt (Yes, No, Unknown) and risk recurrence score (High, Intermediate, Low, Unknown). In our analytic sample (N=833), we propensity score weighted the three test receipt cohorts and used propensity weighted multivariable regressions to examine associations between the outcomes and the three test receipt cohorts, with receipt stratified by score. 29.5% reported an unknown GEP test receipt; 86% being confident. Compared to no test receipt, an intermediate score (aOR, 0.34; 95% CI, 0.20–0.58), unknown score (aOR, 0.09; 95% CI, 0.05–0.18), and unknown test receipt (aOR, 0.37; 95% CI, 0.24–0.57) were less likely to report confidence. Most women greatly overestimated their recurrence risk regardless of their test receipt or score. GEP testing was not associated with greater confidence in chemotherapy decisions. Better communication about GEP testing and the implications for recurrence risk may improve women’s decisional confidence.
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DOI：
10.1056/nejmoa1510764
发表时间：
2015-11-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sparano JA;Gray RJ;Makower DF;Pritchard KI;Albain KS;Hayes DF;Geyer CE Jr;Dees EC;Perez EA;Olson JA Jr;Zujewski J;Lively T;Badve SS;Saphner TJ;Wagner LI;Whelan TJ;Ellis MJ;Paik S;Wood WC;Ravdin P;Keane MM;Gomez Moreno HL;Reddy PS;Goggins TF;Mayer IA;Brufsky AM;Toppmeyer DL;Kaklamani VG;Atkins JN;Berenberg JL;Sledge GW
通讯作者：
Sledge GW
DOI：
10.1056/nejmoa1804710
发表时间：
2018-07-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sparano JA;Gray RJ;Makower DF;Pritchard KI;Albain KS;Hayes DF;Geyer CE Jr;Dees EC;Goetz MP;Olson JA Jr;Lively T;Badve SS;Saphner TJ;Wagner LI;Whelan TJ;Ellis MJ;Paik S;Wood WC;Ravdin PM;Keane MM;Gomez Moreno HL;Reddy PS;Goggins TF;Mayer IA;Brufsky AM;Toppmeyer DL;Kaklamani VG;Berenberg JL;Abrams J;Sledge GW Jr
通讯作者：
Sledge GW Jr
影响因子：
3.5
作者：
Makoul, G;Clayman, ML
通讯作者：
Clayman, ML
影响因子：
3.8
作者：
Peters, E;McCaul, KD;Nelson, W
通讯作者：
Nelson, W
影响因子：
6.2
作者：
Friese, Christopher R.;Li, Yun;Katz, Steven J.
通讯作者：
Katz, Steven J.