Contribution of perfusion pressure to vascular resistance response during head-up tilt.

Contribution of perfusion pressure to vascular resistance response during head-up tilt.
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抬头倾斜期间灌注压对血管阻力反应的贡献。

DOI:
10.1152/ajpheart.2001.281.1.h371
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发表时间:
2001
期刊:
American journal of physiology. Heart and circulatory physiology
影响因子:
--
通讯作者:
Sinoway,LI
Sinoway,LI
中科院分区:
--
文献类型:
--
作者:
Imadojemu,VA;Lott,ME;Gleeson,K;Hogeman,CS;Ray,CA;Sinoway,LI

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在倾斜至40°的试验中,我们测量了8名受试者的肱动脉和股动脉血流速度以及5名受试者的腓和正中肌交感神经活动(MSNA)。在腓神经和正中神经中,肌肉注射引起MSNA类似的增加。股动脉血流速度下降,而肱动脉血流速度无变化。此外,倾斜时,腿部血管阻力(血压/流速)的增加比手臂更大且更持久,腿部与手臂血管阻力增加百分比之比为2.5:1。我们认为,更大的血管阻力在腿的影响是由于交感神经活动和肌源性反应之间的相互作用。
We measured brachial and femoral artery flow velocity in eight subjects and peroneal and median muscle sympathetic nerve activity (MSNA) in five subjects during tilt testing to 40°. Tilt caused similar increases in MSNA in the peroneal and median nerves. Tilt caused a fall in femoral artery flow velocity, whereas no changes in flow velocity were seen in the brachial artery. Moreover, with tilt, the increase in the vascular resistance employed (blood pressure/flow velocity) was greater and more sustained in the leg than in the arm. The ratio of the percent increase in vascular resistance in leg to arm was 2.5:1. We suggest that the greater vascular resistance effects in the leg were due to an interaction between sympathetic nerve activity and the myogenic response.
DOI: 10.1152/jappl.1989.66.6.2778
发表时间: 1989-06
影响因子: 3.3
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