Age-related changes in plasma lycopene concentrations, but not in vitamin E, are associated with fat mass
Age-related changes in plasma lycopene concentrations, but not in vitamin E, are associated with fat mass
复制标题
血浆番茄红素浓度的年龄相关变化与脂肪量相关，但维生素 E 的变化无关
作者：
P. Grolier;Y. Boirie;E. Levadoux;M. Brandolini;P. Borel;V. Azais;B. Beaufrère;P. Ritz
本研究的目的是评估年龄对α-生育酚、视黄醇和类胡萝卜素血浆浓度的影响，特别注意身体组成的自然差异。招募了40名健康受试者：20名小于35岁，20名大于60岁。每个年龄组的男女人数相等。受试者保持能量平衡并接受控制饮食36 h。用180富集水稀释技术测定脂肪质量和去脂质量。血浆维生素A和E，和类胡萝卜素水平测定后12小时禁食，并显示在女性和男性相似。血浆α-生育酚浓度随年龄增加而增加（老年人与年轻人相比增加44%），并与%脂肪量和血浆胆固醇相关。校正血浆胆固醇后，年龄和%脂肪质量的影响消失。与此相反，血浆番茄红素水平是2倍低，在老年人比年轻组，并与脂肪量呈负相关。当番茄红素的值被调整为脂肪量时，年龄的影响消失了。这些结果表明，两个年龄组的血浆维生素E和番茄红素水平不同，血浆胆固醇和脂肪量的差异可能参与了这种效应。短期维生素摄入似乎不会影响血浆维生素浓度。
The aim of the present study was to assess the influence of age on plasma concentration of α-tocopherol, retinol and carotenoids with a special attention paid to natural differences in body composition. Forty healthy subjects were recruited: twenty were less than 35 years old and twenty above 60 years old. Males and females were equally represented in each age group. Subjects were kept in energy balance and received controlled diets for 36 h. Fat mass and fat-free mass were determined with the 180-enriched water dilution technique. Plasma vitamins A and E, and carotenoid levels were determined after 12 h fasting and were shown to be similar in women and men. Plasma α-tocopherol concentration increased with age (+44 % elderly v. young), and correlated with % fat mass and plasma cholesterol. After adjustment for plasma cholesterol, the effect of age and % fat mass disappeared. In contrast, plasma lycopene level was 2-fold lower in the elderly than in the young group, and was inversely correlated with fat mass. When lycopene values were adjusted for fat mass, the effect of age disappeared. These results suggest that plasma levels of vitamin E and lycopene differed in the two age groups and that differences in plasma cholesterol and fat mass might participate in such an effect. Short-term vitamin intake did not appear to influence plasma vitamin concentrations.
老年女性的血浆类胡萝卜素浓度与脂肪量呈负相关。
DOI：
--
发表时间：
1998
期刊：
The journal of nutrition, health & aging.
影响因子：
--
作者：
Yeum,KJ;Booth,SL;Roubenoff,R;Russell,RM
通讯作者：
Russell,RM
人类对口服 β-胡萝卜素的正常血清反应。
影响因子：
3.5
作者：
Henderson,CT;Mobarhan,S;Bowen,P;Stacewicz-Sapuntzakis,M;Langenberg,P;Kiani,R;Lucchesi,D;Sugerman,S
通讯作者：
Sugerman,S