Construction of an oesophageal cancer-specific ceRNA network based on miRNA, lncRNA, and mRNA expression data.
Construction of an oesophageal cancer-specific ceRNA network based on miRNA, lncRNA, and mRNA expression data.
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基于miRNA、lncRNA和mRNA表达数据构建食管癌特异性ceRNA网络
DOI：
10.3748/wjg.v24.i1.23
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发表时间：
2018-01-07
影响因子：
4.3
通讯作者：
Zhao J
中科院分区：
文献类型：
--
作者：
Xue WH;Fan ZR;Li LF;Lu JL;Ma BJ;Kan QC;Zhao J
目的探讨食管鳞状细胞癌（oesophageal squamous cell carcinoma，ESCC）组织中microRNA（microRNAs）、长链非编码RNA（longnoncodingRNAs，lncRNAs）和mRNA的表达谱，构建食管癌特异性竞争性内源性RNA（competitive endogenous RNA，ceRNA）网络。方法收集食管鳞癌组织中miRNAs、lncRNAs和mRNAs的表达数据。然后构建并研究食管癌特异性ceRNA网络。结果CeRNA具有降低miRNA靶向活性的能力，导致具有共同miRNA应答元件的特异性mRNA去抑制。CeRNA相互作用在基因调控和癌症发展中具有关键作用。结论本研究为食管癌的潜在发病机制以及调控ceRNA网络治疗癌症提供了新的视角。
AIM To explore the expression profiles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and mRNAs in oesophageal squamous cell carcinoma (ESCC) in order to construct an oesophageal cancer-specific competing endogenous RNA (ceRNA) network. METHODS In this work, the expression data of miRNAs, lncRNAs, and mRNAs in ESCC were obtained. An oesophageal cancer-specific ceRNA network was then constructed and investigated. RESULTS CeRNAs have the ability to reduce the targeting activity of miRNAs, leading to the de-repression of specific mRNAs with common miRNA response elements. CeRNA interactions have a critical effect in gene regulation and cancer development. CONCLUSION This study suggests a novel perspective on potential oesophageal cancer mechanisms as well as novel pathways for modulating ceRNA networks for treating cancers.
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