NAC selectively inhibit cancer telomerase activity: A higher redox homeostasis threshold exists in cancer cells.
NAC selectively inhibit cancer telomerase activity: A higher redox homeostasis threshold exists in cancer cells.
复制标题
NAC选择性抑制癌症端粒酶活性：癌细胞中存在较高的氧化还原稳态阈值
DOI：
10.1016/j.redox.2015.12.001
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发表时间：
2016-08
期刊：
影响因子：
11.4
通讯作者：
Shi, Dongyun
中科院分区：
文献类型：
--
作者：
Li, Pengying;Wu, Meilin;Wang, Jing;Sui, Yilun;Liu, Shanlin;Shi, Dongyun
Telomerase activity controls telomere length, and this plays an important role in stem cells, aging and tumors. Antioxidant was shown to protect telomerase activity in normal cells but inhibit that in cancer cells, but the underlying mechanism is elusive. Here we found that 7721 hepatoma cells held a higher redox homeostasis threshold than L02 normal liver cells which caused 7721 cells to have a higher demand for ROS; MnSOD over-expression in 7721 decreased endogenous reactive oxygen species (ROS) and inhibited telomerase activity; Akt phosphorylation inhibitor and NAC both inhibited 7721 telomerase activity. The over-elimination of ROS by NAC resulted in the inhibition of Akt pathway. Our results suggest that ROS is involved in the regulation of cancer telomerase activity through Akt pathway. The different intracellular redox homeostasis and antioxidant system in normal cells and tumor cells may be the cause of the opposite effect on telomerase activity in response to NAC treatment. Our results provide a theoretical base of using antioxidants selectively inhibit cancer telomerase activity. Findings of the present study may provide insights into novel approaches for cancer treatment. This study explains why antioxidants selectively inhibit cancer telomerase activity. Cancer cells have higher redox homeostasis threshold than normal cells. ROS is involved in the regulation of cancer telomerase activity through Akt pathway.
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影响因子：
7.5
作者：
Reczek CR;Chandel NS
通讯作者：
Chandel NS
影响因子：
3.9
作者：
Liu, SL;Lin, X;Zhang, YD
通讯作者：
Zhang, YD
影响因子：
--
作者：
Bermudez, Yira;Ahmadi, Shirrin;Kruk, Patricia A.
通讯作者：
Kruk, Patricia A.
影响因子：
56.9
作者：
FENG, JL;FUNK, WD;VILLEPONTEAU, B
通讯作者：
VILLEPONTEAU, B
伊马替尼甲酸酯（Gleevec）下调端粒酶活性，并抑制表达端粒酶的细胞系中的增殖。
影响因子：
8.8
作者：
Uziel, O;Fenig, E;Nordenberg, J;Beery, E;Reshef, H;Sandbank, J;Birenbaum, M;Bakhanashvili, M;Yerushalmi, R;Luria, D;Lahav, M
通讯作者：
Lahav, M