Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches.
Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches.
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衰老的小胶质细胞通过重新编程神经源性微环境促进外周 T 细胞浸润
DOI：
10.1186/s12979-022-00289-6
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发表时间：
2022-07-25
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The immune cell compartment of the mammalian brain changes dramatically and peripheral T cells infiltrate the brain parenchyma during normal aging. However, the mechanisms underlying age-related T cell infiltration in the central nervous system remain unclear. Chronic inflammation and peripheral T cell infiltration were observed in the subventricular zone of aged mice. Cell-cell interaction analysis revealed that aged microglia released CCL3 to recruit peripheral CD8+ memory T cells. Moreover, the aged microglia shifted towards a pro-inflammation state and released TNF-α to upregulate the expression of VCAM1 and ICAM1 in brain venous endothelial cells, which promoted the transendothelial migration of peripheral T cells. In vitro experiment reveals that human microglia would also transit to a chemotactic phenotype when treated with CSF from the elderly. Our research demonstrated that microglia play an important role in the aging process of brain by shifting towards a pro-inflammation and chemotactic state. Aged microglia promote T cell infiltration by releasing chemokines and upregulating adhesion molecules on venous brain endothelial cells. The online version contains supplementary material available at 10.1186/s12979-022-00289-6.
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DOI：
10.1038/s41577-019-0180-1
发表时间：
2019-09
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Goronzy JJ;Weyand CM
通讯作者：
Weyand CM
影响因子：
5.3
作者：
Maslov, AY;Barone, TA;Pruitt, SC
通讯作者：
Pruitt, SC
DOI：
10.1530/vb-19-0033
发表时间：
2020-01-01
期刊：
Vascular biology (Bristol, England)
影响因子：
--
作者：
Marchetti, Luca;Engelhardt, Britta
通讯作者：
Engelhardt, Britta
影响因子：
25
作者：
Munji, Roeben Nocon;Soung, Allison Luen;Daneman, Richard
通讯作者：
Daneman, Richard
影响因子：
32.4
作者：
Mrdjen, Dunja;Pavlovic, Anto;Becher, Burkhard
通讯作者：
Becher, Burkhard