Herpes simplex virus type 2 seroprevalence and associated factors in fertility-treatment-seeking population: A cross-sectional survey in the United Arab Emirates.
Herpes simplex virus type 2 seroprevalence and associated factors in fertility-treatment-seeking population: A cross-sectional survey in the United Arab Emirates.
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单纯疱疹病毒2型血清阳性和寻求生育治疗人群中的相关因素：阿拉伯联合酋长国的横断面调查。
DOI：
10.3389/fpubh.2022.991040
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
Al-Rifai, Rami H. H.
中科院分区：
文献类型：
--
作者：
Abdo, Noor Motea;Aslam, Irfan;Irfan, Shazia;George, Junu A. A.;Alsuwaidi, Ahmed R. R.;Ahmed, Luai A. A.;Al-Rifai, Rami H. H.
关键词：
2型单纯疱疹病毒（HSV-2）是一种常见的生殖器传播病毒感染，影响全球4亿多人。在阿拉伯联合酋长国，在特定的高危人群中，没有关于2型单纯疱疹病毒负担的报告。本研究调查了寻求生育治疗的患者中HSV-2 IgG抗体的流行情况，并确定了HSV-2 IgG抗体血清阳性患者的特征。2021年4月至5月，对在阿联酋阿布扎比一家主要生育诊所寻求生育治疗的患者进行了横断面抽样调查。患者被连续邀请完成自我管理的问卷，并提供血液进行HSV-2检测。收集了社会人口统计学、病史和不孕症的信息。血清标本采用酶联免疫吸附法检测HSV-2 IgG抗体。对299名患者进行了调查并提供了血液样本。患者平均年龄为35.9±6.8岁，女性占89.3%。66%的人超重或肥胖，25.0%的人至少有一种慢性合并症，19.6%的人报告曾经有过生殖器感染。超过三分之二（68.3%）的患者不育≥6个月。42例不育男性中，69.0%精液分析异常。12.4%的患者检出HSV-2 IgG抗体。HSV-2 IgG血清阳性患者的平均年龄（39.5岁对35.4岁，p < 0.001）高于血清阴性患者。男性（15.6%）比女性（12.0%）、继发性不孕（14.1%）比原发性不孕（9.2%）或精液异常（10.3%）比正常（7.7%）的男性（15.6%）更常见。在阿联酋寻求生育治疗的患者中，在任何时候暴露于2型单纯疱疹病毒的比例略高于十分之一。有必要开展针对性的预防2型单纯疱疹病毒的卫生运动。
Herpes simplex virus type 2 (HSV-2) is a common genitally-transmitted viral infection affecting more than 400 million individuals globally. In the United Arab Emirates (UAE), in specific at-risk population groups, the burden of HSV-2 has not been reported. This study investigated the prevalence of HSV-2 IgG antibodies in patients seeking fertility treatment and characterized patients with seropositivity to HSV-2 IgG antibodies. A cross-sectional sample of patients seeking fertility treatment in a major fertility clinic in Abu Dhabi, UAE was surveyed from April to May 2021. Patients were consecutively invited to complete self-administered questionnaires and provide blood for HSV-2 testing. Information on sociodemographics, medical history, and infertility was collected. Serum specimens were screened using an enzyme-linked immunosorbent assay for HSV-2 IgG antibodies detection. Two hundred and ninety-nine patients were surveyed and provided blood samples. The mean age of the patients was 35.9 ± 6.8 [mean ± standard deviation (SD)] years with 89.3% being women. Sixty-six percent were overweight or obese, 25.0% had at least one chronic comorbidity, and 19.6% reported ever-had genital infection. More than two-thirds (68.3%) of the patients were infertile for ≥ 6 months. Of the 42 infertile males, 69.0% had an abnormal semen analysis. HSV-2 IgG antibodies was detected in 12.4% of patients. The HSV-2 IgG seropositive patients had a higher mean age (39.5 vs. 35.4 years; p < 0.001) compared to seronegative patients. HSV-2 IgG antibodies seropositivity was more common in males (15.6%) than females (12.0%), in patients with secondary (14.1%) vs. primary (9.2%) infertility, or in males with abnormal (10.3%) vs. normal (7.7%) semen. Exposure to HSV-2 at any time in patients seeking fertility treatment in the UAE was found to be slightly common in more than one out of 10 patients. Tailored health campaigns on HSV-2 prevention are warranted.
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DOI：
10.1016/s1473-3099(17)30405-x
发表时间：
2017-12
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Looker KJ;Elmes JAR;Gottlieb SL;Schiffer JT;Vickerman P;Turner KME;Boily MC
通讯作者：
Boily MC
人乳头瘤病毒和沙眼衣原体诱导的促炎和氧化应激状态会影响无症状不育男性的精子质量。
DOI：
10.3390/medicina57090862
发表时间：
2021-08-24
期刊：
Medicina (Kaunas, Lithuania)
影响因子：
--
作者：
Pérez-Soto E;Fernández-Martínez E;Oros-Pantoja R;Medel-Flores O;Miranda-Covarrubias JC;Sánchez-Monroy V
通讯作者：
Sánchez-Monroy V
单纯疱疹病毒的无症状精液感染：对男性不育症的影响。
影响因子：
2.3
作者：
Monavari SH;Vaziri MS;Khalili M;Shamsi-Shahrabadi M;Keyvani H;Mollaei H;Fazlalipour M
通讯作者：
Fazlalipour M
影响因子：
11.8
作者：
Bernstein, David I.;Bellamy, Abbie R.;Belshe, Robert B.
通讯作者：
Belshe, Robert B.
影响因子：
3.7
作者：
Looker KJ;Magaret AS;Turner KM;Vickerman P;Gottlieb SL;Newman LM
通讯作者：
Newman LM