Do Mouse Cerebellum Astrocytes Play a Role in Neuronal Survival and Differentiation
Do Mouse Cerebellum Astrocytes Play a Role in Neuronal Survival and Differentiation
复制标题
小鼠小脑星形胶质细胞在神经元存活和分化中发挥作用吗
DOI：
--
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
F. Alliot
中科院分区：
文献类型：
--
作者：
B. Pessac;F. Alliot
小脑是中枢神经系统（CNS）的一个区域，由于其少数神经元细胞类型的发育、电路和性质得到充分研究，其经常被用作模型（Eccles et al. 1967年; Palay和Chan-Palay，1974年）。有人提出，在小脑中，一些星形胶质细胞具有建筑作用。事实上，在胚胎发育后期，高尔基体上皮细胞（其细胞体位于浦肯野细胞层）将放射状星形胶质细胞突起（Bergmann纤维）延伸至小脑皮质的软膜表面，可能是为了引导颗粒细胞神经元从脑室区迁移至外部颗粒层（Rakic，1971; De Bias，1984）。此外，星形胶质细胞将有丝分裂后的成熟神经元组织成隔室;特别是有证据表明，帆状原生质星形胶质细胞的突起形成隔室，隔室隔开含有颗粒细胞体群的层状、面纱样隔室（Palay and Chan-Palay，1974）。
The cerebellum is a region of the central nervous system (CNS) that has often been used as a model because of the well-studied development, circuitry, and properties of its few neuronal cell types (Eccles et al., 1967; Palay and Chan-Palay, 1974). It has been proposed that, in cerebellum, some astroglial cells have an architectonic role. Indeed, during late embryonic development, the Golgi epithelial cells, whose bodies are located in the Purkinje cell layer, extend radial astroglial processes, the Bergmann fibers, to the pial surface of the cerebellum cortex, probably to guide the migration of granule cell neurons from the ventricular zone to the external granular layer (Rakic, 1971; De Bias, 1984). In addition, the astroglia organizes postmitotic mature neurons into compartments; in particular there is evidence that the processes of the velate protoplasmic astrocytes form septa that wall off lamellar, veil-like compartments that contain groups of granule cell bodies (Palay and Chan-Palay, 1974).
影响因子：
56.9
作者：
COWAN, WM;FAWCETT, JW;STANFIELD, BB
通讯作者：
STANFIELD, BB