New Monoterpenoid Indoles with Osteoclast Activities from Gelsemium elegans.
New Monoterpenoid Indoles with Osteoclast Activities from Gelsemium elegans.
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DOI：
10.3390/molecules26247457
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发表时间：
2021-12-09
期刊：
影响因子：
--
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Wei X;Guo R;Wang X;Liang JJ;Yu HF;Ding CF;Feng TT;Zhang LY;Liu X;Hu XY;Zhou Y
钩吻是我国民间治疗骨折、皮肤溃疡的常用药，历史悠久。本文报道了两个新的单萜吲哚生物碱gelselegandines D和E以及已知的类似物gelegamine A。优雅通过光谱技术和量子化学计算确定了它们的结构。测试所有分离的化合物对RANKL诱导的破骨细胞形成的影响。有趣的是，gelselegandine E和gelegamine A，分别显示出显着的促进和抑制破骨细胞生成的活动，而gelselegandine D在相同的浓度下没有活性。本研究结果表明，这些化合物的C-19/20氧环附近的碳原子构型不同，可能是其对破骨细胞形成的关键活性基团，为G.优雅的
The well-known toxic medicine Gelsemium elegans is widely and historically used to treat bone fracture and skin ulcers by the folk people of China. Two new monoterpenoid indole alkaloids, gelselegandines D and E, together with the known analogue gelegamine A were isolated from G. elegans. Their structures were elucidated by means of spectroscopic techniques and quantum chemical calculations. All isolated compounds were tested for the effects on RANKL-induced osteoclast formation. Interestingly, gelselegandine E and gelegamine A, respectively, showed significant promoting and inhibitory activities on osteoclastogenesis, while gelselegandine D had no activity under the same concentration. This work suggested the different configurations for the carbons near the C-19/20 oxygen rings of the isolated compounds may be the key active groups on osteoclast formation and provided the evidence for the rationality as the traditional treatment for bone-related diseases of G. elegans.
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