A multimodal sono-contrast NIR spectroscopy system for breast cancer Diagnosis: System design and safety considerations
A multimodal sono-contrast NIR spectroscopy system for breast cancer Diagnosis: System design and safety considerations
复制标题
用于乳腺癌诊断的多模态声对比近红外光谱系统：系统设计和安全考虑
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
L. Liao
中科院分区：
文献类型：
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作者：
K. Yan;Ke Huang;T. Podder;Yan Yu;L. Liao
本文提出了一种新型的多模态成像系统，该系统结合了光谱学、超声和声辐射力（ARF），以提高基于血管无创探查的乳腺癌诊断。详细介绍了系统的硬件设计和软件设计。患者安全相关的考虑也在本文中讨论。已经进行了相应的校准和测试。基于安全指南，激光对皮肤的最大暴露量控制在0.2 W·cm−2以内；ARF场暴露量保持在FDA诊断限值（0.72 W·cm−2）以下，漏电控制在300µA以下。这种多模态系统有可能通过部署ARF在组织血液供应环境的动态行为中产生可测量的差异来改善肿瘤检测，这在小鼠肿瘤模型中被证明是高度诊断的。正在进行临床试验研究。
This paper presents a novel multimodal imaging system, which combines optical spectroscopy, ultrasonography and acoustic radiation force (ARF) for improving diagnosis of breast cancer based on noninvasive interrogation of vasculature. System design including both hardware and software is described in detail. Patient safety related considerations are also addressed in this paper. Calibrations and tests have been performed accordingly. Based on safety guidelines, the maximum exposure to skin for laser was controlled within 0.2 W·cm−2; exposure from ARF fields were maintained below the FDA diagnostic limit (0.72 W·cm−2), and electrical leakage was controlled below 300 µA. This multimodal system has the potential to improve tumor detection by deploying ARF to produce a measurable difference in the dynamic behavior of the tissue blood supply environment as interrogated by optical spectroscopy, which was demonstrated to be highly diagnostic in a murine tumor model. Pilot clinical study is being carried out.
影响因子：
4.8
作者：
Ntziachristos, V;Yodh, AG;Chance, B
通讯作者：
Chance, B