In utero exposure to low-doses of ionizing radiation decelerates neuronal migration in the developing rat brain.
In utero exposure to low-doses of ionizing radiation decelerates neuronal migration in the developing rat brain.
复制标题
在子宫内暴露于低剂量的电离辐射会减缓发育中的大鼠大脑中的神经元迁移。
DOI：
10.1080/095530096145328
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发表时间：
1996
影响因子：
2.6
通讯作者：
W. Schull
中科院分区：
文献类型：
--
作者：
S. Fushiki;K. Matsushita;H. Yoshioka;W. Schull
为了阐明低剂量电离辐射对发育中的大鼠大脑皮层影响的可能机制，我们研究了产前子宫内辐射如何影响神经元迁移。我们已经证明了低至 15 cGy 剂量的电离辐射对神经元迁移的影响以及神经细胞粘附分子 N-CAM 表达模式的变化。剂量为 15 cGy 或更高后，基质细胞区中的 N-CAM 免疫反应性降低，这种降低在暴露后约 24 小时变得明显，并持续到暴露后 48 小时。暴露于辐射后 3 天发生正常反应。然而，L1、MAP2、tau 蛋白或神经丝的免疫反应性没有明显变化。我们的研究结果表明 N-CAM 在神经元迁移中可能发挥作用，并且还表明小辐射剂量对发育中的大脑皮层的影响存在阈值。
In order to elucidate the possible mechanisms for the effects of low doses of ionizing radiation on the developing rat cerebral cortex we studied how neuronal migration can be affected by prenatal in utero irradiation. We have demonstrated an effect of ionizing radiation on neuronal migration at doses as low as 15 cGy together with a changing pattern of expression of the neural cell adhesion molecule N-CAM. After a dose of 15 cGy or more there was a reduction in N-CAM immunoreactivity in the matrix cell zone which became apparent about 24 h after exposure and continued until 48 h after exposure. Normal reactivity occurred 3 days after exposure to radiation. However, there was no obvious change in the immunoreactivity for L1, MAP2, tau protein or neurofilament. Our findings suggest the possible role of N-CAM in neuronal migration and also suggest the presence of a threshold in terms of the effects of small radiation doses on the developing cerebral cortex.
内源性蛋白酶、mRNA 水平和胰岛素作为视网膜发育过程中 N-钙粘蛋白下调的多种机制的证据。
DOI：
10.1242/dev.114.4.973
发表时间：
1992
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Roark,EF;Paradies,NE;Lagunowich,LA;Grunwald,GB
通讯作者：
Grunwald,GB
影响因子：
56.9
作者：
RUTISHAUSER, U;ACHESON, A;SUNSHINE, J
通讯作者：
SUNSHINE, J