The transcriptome: malariologists ride the wave.
The transcriptome: malariologists ride the wave.
复制标题
转录组：疟疾学家乘势而上。
作者：
R. Wilson
恶性疟原虫基因组测序项目为疟疾学家提供了大量与细胞过程相关的新信息，这些信息以前只是猜测。在探索这些被预测的基因和蛋白质的泥沼时，现在存在着简单地重新发明细胞的危险。幸运的是，新的全球转录分析让疟疾学家放心，他们处理的不是“任何一个老细胞”。Le Roch等人（2003）1和Bozdech等人（2003）2在恶性疟原虫的基因组学和蛋白质组学之间架起了一座桥梁。它们很可能成为未来许多研究的支点：例如，对监管和反馈回路的研究。
The Plasmodium falciparum genome-sequencing project has provided malariologists with vast amounts of new information pertinent to a multitude of cellular processes that previously were only guessed about. In exploring this morass of predicted genes and proteins, there is now a danger of simply re-inventing the cell. Fortunately, new global transcriptional analyses reassure malariologists that they are not dealing with just "any old cell." The informative papers on the plasmodial transcriptome by Le Roch et al. (2003)1 and Bozdech et al. (2003)2 discussed below forge a bridge between the genomics and proteomics of P. falciparum. They are likely to act as a fulcrum upon which much future research will turn: for example, the study of regulation and feed-back loops.
影响因子：
3.3
作者：
Spellman, PT;Sherlock, G;Futcher, B
通讯作者：
Futcher, B