Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain.
Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain.
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DOI：
10.3389/fnins.2016.00373
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发表时间：
2016
影响因子：
4.3
通讯作者：
Murphy E
中科院分区：
文献类型：
--
作者：
Benítez-Burraco A;Lattanzi W;Murphy E
Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders entailing social and cognitive deficits, including marked problems with language. Numerous genes have been associated with ASD, but it is unclear how language deficits arise from gene mutation or dysregulation. It is also unclear why ASD shows such high prevalence within human populations. Interestingly, the emergence of a modern faculty of language has been hypothesized to be linked to changes in the human brain/skull, but also to the process of self-domestication of the human species. It is our intention to show that people with ASD exhibit less marked domesticated traits at the morphological, physiological, and behavioral levels. We also discuss many ASD candidates represented among the genes known to be involved in the “domestication syndrome” (the constellation of traits exhibited by domesticated mammals, which seemingly results from the hypofunction of the neural crest) and among the set of genes involved in language function closely connected to them. Moreover, many of these genes show altered expression profiles in the brain of autists. In addition, some candidates for domestication and language-readiness show the same expression profile in people with ASD and chimps in different brain areas involved in language processing. Similarities regarding the brain oscillatory behavior of these areas can be expected too. We conclude that ASD may represent an abnormal ontogenetic itinerary for the human faculty of language resulting in part from changes in genes important for the “domestication syndrome” and, ultimately, from the normal functioning of the neural crest.
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影响因子：
2
作者：
Bisaz, Reto;Boadas-Vaello, Pere;Sandi, Carmen
通讯作者：
Sandi, Carmen
影响因子：
3.8
作者：
Boeckx C;Benítez-Burraco A
通讯作者：
Benítez-Burraco A
影响因子：
2.9
作者：
Bitsika, Vicki;Sharpley, Christopher F.;Agnew, Linda L.
通讯作者：
Agnew, Linda L.
影响因子：
9.8
作者：
Benayed, R;Gharani, N;Millonig, JH
通讯作者：
Millonig, JH
DOI：
10.1126/science.1241006
发表时间：
2013-10-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Attanasio C;Nord AS;Zhu Y;Blow MJ;Li Z;Liberton DK;Morrison H;Plajzer-Frick I;Holt A;Hosseini R;Phouanenavong S;Akiyama JA;Shoukry M;Afzal V;Rubin EM;FitzPatrick DR;Ren B;Hallgrímsson B;Pennacchio LA;Visel A
通讯作者：
Visel A