Effect of atorvastatin on chronic periodontitis: a randomized pilot study.
Effect of atorvastatin on chronic periodontitis: a randomized pilot study.
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阿托伐他汀对慢性牙周炎的影响：一项随机试点研究。
DOI：
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发表时间：
2010
影响因子：
6.7
通讯作者：
Emanuel Jaime Espinosa
中科院分区：
文献类型：
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作者：
M. E. Fajardo;M. L. Rocha;F. J. Sánchez;Emanuel Jaime Espinosa
目的
我们研究了阿托伐他汀 (ATV) 治疗对预防慢性牙周炎受试者骨质流失的影响。
材料和方法
在这项对照双盲研究中，38 名患有慢性牙周炎的受试者被随机分为两组，按年龄配对，每天接受 ATV（20mg）或安慰剂，持续 3 个月。两组在基线时均进行牙周机械治疗。在基线和 3 个月时评估临床和放射学参数以及骨转换标志物。
结果
两组的牙周病状况均有所改善。比较变化数字后，胆固醇水平（Δ=-58.5 ± 37.6 对比 Δ=5.4 ± 41.2 mg/dl，p<0.0002）、低密度脂蛋白水平（Δ=-48.1 ± 31.7 对比 Δ=1.9 ± 42.8 mg/dl，p<0.002）、牙齿松动度均有显着改善ATV 组中（Δ=-0.17 ± 0.11 对比 Δ=-0.06 ± 0.11%，p<0.04），以及牙槽嵴牙槽骨到牙骨质-牙釉质接合处的距离（Δ=-0.75 ± 0.7 对比Δ=0.09 ± 0.4 mm，p<0.0006）。
结论
结果表明，ATV 可能对牙周病患者的骨牙槽丢失和牙齿松动产生有益影响。
AIM
We studied the effect of atorvastatin (ATV) treatment on bone loss prevention in subjects with chronic periodontitis.
MATERIAL AND METHODS
In this controlled double-blind study, 38 subjects with chronic periodontitis were randomized into two groups, paired by age to receive ATV (20 mg) or placebo daily for 3 months. Periodontal mechanical treatment was carried out in both groups at baseline. Clinical and radiographic parameters and bone turnover markers were assessed at baseline and at 3 months.
RESULTS
Periodontal disease conditions improved in both groups. After comparing the figures of change, significant improvements were observed in cholesterol levels (Δ=-58.5 ± 37.6 versusΔ=5.4 ± 41.2 mg/dl, p<0.0002), low-density lipoprotein levels (Δ=-48.1 ± 31.7 versusΔ=1.9 ± 42.8 mg/dl, p<0.002), dental mobility (Δ=-0.17 ± 0.11 versusΔ=-0.06 ± 0.11%, p<0.04), and the distance from the crestal alveolar bone to the cemento-enamel junction (Δ=-0.75 ± 0.7 versusΔ=0.09 ± 0.4 mm, p<0.0006) in the ATV group.
CONCLUSIONS
The results suggest that ATV might have beneficial effects on bone alveolar loss and tooth mobility in subjects with periodontal disease.
影响因子：
4.3
作者：
Stein, D;Lee, YJ;Reinhardt, RA
通讯作者：
Reinhardt, RA
DOI：
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发表时间：
2003
期刊：
Journal of the International Academy of Periodontology
影响因子：
--
作者：
C. Cutler;A. Iacopino
通讯作者：
C. Cutler;A. Iacopino
影响因子：
37.8
作者：
Maron, DJ;Fazio, S;Linton, MF
通讯作者：
Linton, MF